by a short BrdU pulse, indicating that prevention of Bmi1 downregulation does not drive granule cells back into the cell cycle. No tumours were observed in two aging cohorts of transgenic mice derived from separate founder lines. However, these mice display an increase in astrocytes with the type II morphology in vitro compared to wild-type littermates. Cultures of FACSorted Math1-GFP+ granule ...

The rate of migration of immature granule cells of the rat olfactory bulb and polarity of cell-organelles in the migrating granule cells were investigated by 3H-thymidine autoradiographic and electron microscopic methods. The time lag in migration between two points was determined by cross-correlation analysis of labeling indices of the two areas. Granule cells were estimated to take 6 days to ...

Patients and models of temporal lobe epilepsy have fewer inhibitory interneurons in the dentate gyrus than controls, but it is unclear whether granule cell inhibition is reduced. We report the loss of GABAergic inhibition of granule cells in the temporal dentate gyrus of pilocarpine-induced epileptic rats. In situ hybridization for GAD65 mRNA and immunocytochemistry for parvalbumin and somatost...

by a short BrdU pulse, indicating that prevention of Bmi1 downregulation does not drive granule cells back into the cell cycle. No tumours were observed in two aging cohorts of transgenic mice derived from separate founder lines. However, these mice display an increase in astrocytes with the type II morphology in vitro compared to wild-type littermates. Cultures of FACSorted Math1-GFP+ granule ...

In humans and experimental animals, structural and functional changes in neural circuits can accompany the development of epilepsy. In the dentate gyrus, seizures enhance adult neurogenesis, but it is unclear to what extent newborn granule cells participate in seizureinduced synaptic reorganization. During the first weeks of their existence, mouse newborn granule cells labeled with enhanced gre...

Normal aging comprises cognitive decline, including deterioration of memory. It has been suggested that this decline in memory is sexually dimorphic because of the cessation in gonadal steroid secretion that occurs during reproductive aging in female, but not male, mammals. We wondered whether neurons in brain regions associated with learning and memory underwent morphological changes that were...

by a short BrdU pulse, indicating that prevention of Bmi1 downregulation does not drive granule cells back into the cell cycle. No tumours were observed in two aging cohorts of transgenic mice derived from separate founder lines. However, these mice display an increase in astrocytes with the type II morphology in vitro compared to wild-type littermates. Cultures of FACSorted Math1-GFP+ granule ...

Growth cone extension is guided by extracellular factors during the brain development but the underlying cellular mechanisms remain largely unclear. Here, we examined the potential function of class-3 semaphorins in cultured cerebellar granule cells. We found neuropilin-2 (NP2), the high-affinity receptor for semaphorin-3F (Sema3F), is highly expressed in cerebellar granule cells. An extracellu...