OBJECTIVE To present a case of culture-proven typhoid fever in which granulomas were demonstrated histologically in the ileum and mesenteric lymph nodes. CLINICAL PRESENTATION AND INTERVENTION A 47-year-old Pakistani man underwent emergency hemicolectomy for severe bleeding per rectum associated with diarrhea. Two large ulcers in the ileum, near the ileocolic junction, as well as mesenteric l...

Lichenoid and granulomatous dermatitis is a new entity which is histologically defined by a band like lymphocytic infiltration in the upper portion of the dermis with obscuring the dermoepidermal junction and accompanied by basal layer degeneration and granulomatous inflammation. Herein, we presented two Iranian women with similar cutaneous and histopathologic findings. Both patients had asympt...

Beryllium induces non-caseating granulomatous inflammation in humans exposed to the metal dust or fumes in both occupational and non-occupational settings. The resulting condition, chronic beryllium disease (CBD), affects principally the lungs, lymphatics, and skin and continues to plague modern industry. Beryllium exerts several important immunotoxic effects, including induction of a beryllium...

granulomatous mastitis (gm) is a rare breast disease with unknown etiology. clinical management strategies for gm include surgery, antibiotics, and steroid treatments. as patients with gm often respond to steroids, gm is thought to be an autoimmune disease. here we describe a case of trauma?induced gm that presented as autoimmune disease but was successfully treated by surgery without steroids....

INTRODUCTION The occurrence of granulomatous disease in the setting of Hodgkin's disease is rare; however, when it occurs it can pose significant clinical and diagnostic challenges for physicians treating these patients. CASE PRESENTATION We report the case of a 33-year-old Caucasian woman of Mediterranean descent with newly diagnosed 18F-fluorodeoxyglucose (18F-FDG) positron emission tomogra...

The role of reduced glutathione in relation to hexose monophosphate shunt activity and peroxide detoxification has been well established in human erythrocytes. Less is known about the content of reduced glutathione in phagocytic leukocytes and the changes that occur during functional activity. We have measured the reduced sulfhydryl content of normal resting human granulocytes and of cells isol...

in chronic granulomatous disease (cgd) patients, esophageal stricture is a rare complication and the treatment of choice is still controversial. there are few reports of successful therapy with antibiotics, corticosteroids, multiple balloon dilatations or their combination. we report a 3-three-year-old iranian boy with recurrent esophageal obstruction due to cgd. the patient transiently respond...

churg-strauss syndrome (css) is a granulomatous small vessel vasculitis . it is characterized by asthma, allergic granulomatosis and vasculitis . this syndrome is rare in children. a 5 years old boy was admitted with cough, fever and dyspnea for 2 weeks. on the basis of  laboratory data (peripheral eosinophilia), associated with skin biopsy, and history of css in his sister, this disease was ev...

Chronic beryllium disease (CBD) is characterized by granulomatous inflammation and the accumulation of CD4(+) T cells in the lung. Patch testing of CBD patients with beryllium sulfate results in granulomatous inflammation in the skin. We investigated whether the T cell clonal populations present in the lung of CBD patients would also be present in the involved skin of a positive beryllium patch...