The function of inhibitory interneurons within brain microcircuits depends critically on the nature and properties of their excitatory synaptic drive. Golgi cells (GoCs) of the cerebellum inhibit cerebellar granule cells (GrCs) and are driven both by feedforward mossy fiber (mf) and feedback GrC excitation. Here, we have characterized GrC inputs to GoCs in rats and mice. We show that, during su...

BACKGROUND In 2007, WHO established the Guidelines Review Committee (GRC) to ensure that WHO guidelines adhere to the highest international standards. The GRC reviews guideline proposals and final guidelines. The objectives of this study were to examine the rates of and reasons for conditional approval and non-approval of documents submitted for the first time to the GRC, and calculate the time...

The appropriateness of normalizing data, as one method to reduce the effects of a covariate on a dependent variable, should be evaluated. Using ratio, 0.67-nonlinear, and fitted normalizations, the aim of this study was to investigate the relationship between ground reaction force variables and body mass (BM). Ground reaction forces were recorded for 40 female subjects running at 3.7 +/- 0.18 m...

Drug-resistant cell lines are essential tools for investigating the mechanisms of resistance to molecular-targeted anti-cancer drugs. However, little is known about how to establish clinically relevant drug-resistant cell lines. Our study examined the impact of a drug-free period on the establishment of a cell line with clinically relevant resistance to molecular-targeted drugs. We used PC9 cel...

OBJECTIVES We investigated whether high gender role conflict (GRC; internal conflict with traditional gender-role stereotypes and an individual's perceived need to comply with these roles) is associated with psychological distress and HIV-related risk behaviors in a sample of African American men who have sex with men and women (MSMW). METHODS We analyzed baseline data collected from question...

The Genetic Resource Center (GRC) is a centralized process for requesting genetic testing that is not available within the province (Alberta, Canada). In order to assess potential cost savings associated with this process, all applications received by the GRC in 2010 were reviewed, and cost savings were recorded for statistical analysis. Seven areas of cost savings were identified: (i) negotiat...

Granular Computing (GrC), a knowledge-oriented computing which covers the theory of fuzzy information granularity, rough set theory, the theory of quotient space and interval computing etc, is a way of dealing with incomplete, unreliable, uncertain fuzzy knowledge. In recent years, it is becoming one of the main study streams in Artificial Intelligence (AI). With selecting the size structure fl...

Industry uses GRC frameworks for compliance management and tracking. These are document-oriented systems that help human experts maintain traceability between various artefacts in the compliance life-cycle. Documents such as legal text of regulations, compliance process descriptions, audit reports, etc. can be linked using tagging mechanisms. Actual implementation of compliance to regulations h...

Incremental dynamic analysis (IDA) requires the analysis of the non-linear response history of a structure for an ensemble of ground motions, each scaled to multiple levels of intensity and selected to cover the entire range of structural response. Recognizing that IDA of practical structures is computationally demanding, an approximate procedure based on the reduction of the number of ground m...