Generalized tonic-clonic seizures (GTCS) are the main risk factor for sudden unexpected death in epilepsy (SUDEP). Also, among several mechanisms underlying SUDEP there is cardiac dysfunction. So, we aimed to evaluate impact of number on heart function and morphology rats with epilepsy. Rats were randomized into three groups: Sham (without epilepsy), 5 S, 10 S groups, referred as a total or GTC...

An important role for oxidative stress both as a consequence and as a cause of epileptic seizures has been suggested. Since Achillea wilhelmsii (A. wilhelmsii) has been considered to have the antioxidant effects as well as central nervous system depressant properties, the anti-seizure effects of the plant extract in addition to its effects on brain tissues oxidative damage were investigated in ...

Flavonoids are important constituents of food and beverages, and several studies have shown that they have neuroactive properties. Many of these compounds are ligands for γ-aminobutyric acid type A receptors in the central nervous system. This study aimed to investigate the anticonvulsant effects of quercetin (3,3',4',5,7-pentahydroxyflavone), which is a flavonoid found in plants, in rats treat...

Green tea catechins (GTCs) are secondary plant metabolites that have been associated with health benefits in human trials. As such, they have the potential to reduce cardiovascular disease (CVD) risk; however, results are not consistent. This systematic review of the published data assessed the putative effect of GTCs supplementation on anthropometric, blood pressure, and biochemical measures a...

Genetic and antigenic characterizations of 70 strains of adenovirus type 41 (Ad41), isolated between 1998 and 2001 from children in Japan, Vietnam, and Korea, were done by DNA restriction enzyme (RE) analysis, sequencing analysis, and monoclonal antibody (MAb)-based enzyme-linked immunosorbent assay (ELISA). Eight genome types were observed in the present study, among which D25, D26, D27, and D...

AIMS Valproic acid (VPA) is reported to be effective for the control of absence seizures in 75% of children. The aim of this study was to determine the clinical and socio-demographic factors associated with VPA response in newly diagnosed childhood absence epilepsy (CAE) and to determine if these factors also influence the chances of achieving long-term seizure freedom. METHODS Medical charts...

The effects of hypoxia on susceptibility to pentylenetetrazol (PTZ)-induced seizures were assessed in juvenile rats. Animals at postnatal (P) day 25 were exposed to hypobaric hypoxia (simulated altitude of 7000 m) for 8 h PTZ in a dose of 100 mg/kg was injected 1, 3 or 7 days later and latency, pattern and severity of seizures were registered. Mortality due to seizures was also evaluated. Two s...

Chronic inflammation raises the risk of the development of colorectal cancer (CRC). Green tea catechins (GTCs), which possess anti-inflammatory properties, are known to be anti-carcinogenic in a variety of organ sites, including the colorectum. This study investigated whether (-)-epigallocatechin gallate (EGCG), a candidate chemopreventive agent and major biologically-active component of green ...

BACKGROUND/AIM The effects of coadministration of melatonin and theanine (Mel/Thea) on pentylenetetrazole (PTZ)-induced seizures and brain tissue oxidative damage were investigated in ovariectomized (OVX) and sham-operated rats. MATERIALS AND METHODS The rats were divided into the following groups: 1) sham, 2) ovariectomized (OVX), 3) sham-PTZ, 4) OVX- PTZ, 5) sham-Mel/Thea-PTZ, and 6) OVX-Me...

BACKGROUND Epidemiological evidence indicates epilepsy is more common in patients with autism spectrum disorders (ASD) (20-25%) than in the general population. The aim of this project was to analyze seizure susceptibility in developing rats prenatally exposed to valproic acid (VPA) as autism model. METHODS Pregnant females were injected with VPA during the twelfth embryonic day. Seizures were...