Present study was designed to minimize the drug release in upper gastro intestinal tract and target to colon by using the principles of compression coat. Compression coated tablets are prepared by direct compression method using guar gum alone (or) combination of guargum/metalose 90 SH polymers. Tablets are evaluated for their physicochemical properties and in vitro drug release studies. All th...

The aim of study is to develop colon targeted system for metronidazole using guar gum and xanthan gum. Matrix formulations containing various proportions of guar gum and xanthan gum were prepared by wet granulation technique. Later on, multilayer tablets were prepared by using 50 mg and 100 mg of guar gum as release controlling layer on either side of (M5) matrix tablets of metronidazole. The i...

Recent studies focus on the chemical modification of polysaccharides for biomedical applications. Guar gum is a natural polymer composed of linear chains of (1-4)-β-D mannopyranosyl units with α-Dgalactopyranosyl units attached by (1-6) linkages, in a ratio of about 1.5-2, possessing hydroxyl groups available for the attachment of biologically active compounds. The modifications here discussed ...

The present paper describes development of a polysaccharide based compression coated tablets of secnidazole for colon delivery. Core tablet containing secnidazole was compression coated with various proportions of guar gum, xanthan gum and chitosan, either alone or in combinations. Drug release studies were performed in simulated gastric fluid (SGF) for 2 h followed by simulated intestinal flui...

Purpose: To compare the mucoadhesive performance of grewia polysaccharide gum with those of guar gum, carboxymethylcellulose, hydroxypropyl methylcellulose and carbopol 971P. Methods: Grewia polysaccharide gum compacts or gels as well as those of guar gum, carboxymethylcellulose, hydroxypropyl methylcellulose or carbopol 971P were prepared. Texturometric and tensile analysis of the polymer gels...

Experiments were carried out in vitro with three viscous polysaccharides (guar gum, pectin, and carboxymethylcellulose (CMC) of similar initial viscosity submitted to conditions that mimic events occurring in the stomach and duodenum, and their viscosity in these situations was compared to their actions on postprandial hyperglycemia in normal human subjects. Guar gum showed greater viscosity th...

In this study, the effect of different hydrocolloid combination and storage period on physicochemical, textural sensory characteristics keşkül, a dairy dessert, was determined. Guar gum-xanthan gum, carrageenan-guar gum carrageenan-xanthan combinations were assessed as in keşkül production. Some textural, properties determined days 1, 5 10 storage. Keşkül samples containing carrageenan had high...

Prolonged residence of drug formulation in the nasal cavity is important for the enhancing intranasal drug delivery. The objective of the present study was to develop a mucoadhesive in-situ gelling nasal insert which would enable the reduced nasal mucociliary clearance in order to improve the bioavailability of metoclopramide hydrochloride. Metoclopramide hydrochloride is a potent antiemetic an...

saturated fat consumption increases the risk of both coronary and cancer diseases. therefore, fat reduction in uf-feta cheese (≈ 45% fdm) is favorable but, unfortunately, it has some negative effects on the texture and sensory characteristics of the cheese. in this research, response surface methodology was employed to study the probably improving effects of wpc80 (0-20 gr kg-1), lecithin (0-2 ...

To reduce time-dependent aggregation phenomena and achieve true "molecular" solution, the "pressure cell" solubilization method of Vorwerg and co-workers was applied to solutions of guar galactomannans (three samples of different molecular weights), using various heating, time, and pressure profiles. Physicochemical characterization of the guar samples before and after pressure cell treatment i...