Background: The seeds of Nigella sativa plant have been used to promote health and fight disease for centuries especially in the Middle East and Southeast Asia. This plant has been a great focus of research. This clinical study was undertaken to determine the adjuvant effect of Nigella sativa oil on various clinical and biochemical parameters of the metabolic syndrome. Methodology: This prospec...

BACKGROUND Vitiligo is one of the autoimmune skin diseases that destroy the melanocytes of the skin. Moreover, its prevalence varies in different countries and regions. OBJECTIVES The aim of this study was to compare the effect of Nigella sativa and fish oil on vitiligo lesions of the patients referred to a dermatology clinic. MATERIALS AND METHODS This randomized, double blind clinical tri...

Introduction: Amphotericin B is considered as one of the most effective antifungal drugs presently used to treat systemic fungal infections; however, nephrotoxicity remains the major side effect. The current study is therefore, designed to determine Amphotericin B induced nephrotoxicity and its prevention by administration of Nigella sativa (NS) extract in albino mice. Materials and Methods: Th...

Four commonly used spices plants in Iran were evaluated for cytotoxicity effect using Brine Shrimp Lethality (BSL) assay. Essential oils and various extracts of Heracleum persicum, Nigella arvensis, Cinnamomum zeylanicum and Zingiber officinale were assessed by two methods of disk and solution of BSL. Data were processed in probit-analysis program to estimate LC50 values. All of the tested frac...

introduction: the immunogenicity of crude amoebic antigen and its fractions preparedfrom entamoeba histolytica (nih:200) was evaluated in experimental animals. material and methods: forty two guinea pigs of either sex free from entamoebainfection and aged around 3 to 4 weeks were randomly divided into 5 groups. the treatedgroups consisted of 8, 10, 6, and 8 animals and 10 animals served as cont...

Moringa stenopetala, a plant belonging to the family of Moringaceae, is traditionally used for the treatment of hypertension and diabetes in Ethiopia. This study evaluates the in vitro vasodilatory effect of the extract of M. stenopetala leaves and the possible mechanisms in precontracted isolated thoracic aorta of guinea pigs. A guinea pig was sacrificed by gentle cervical dislocation, and the...

Black Seed The date and location of domestication of Nigella sativa is not clearly established, but the plant was certainly under wide cultivation more than 3000 years ago, when it was placed in the tomb of Egyptian King Tutankhamun. Historical evidence also shows contemporaneous, or earlier, black seed cultivation in Jordan and Iraq. In addition, wild types of Nigella sativa grow in Turkey, Sy...

All animals, except for the placental mammals, conjugate their bile acids exclusively with taurine. However, in certain of the placental mammals, glycine conjugates are also found. The basis for the appearance of glycine conjugation among the placental mammals was investigated. The reaction of choloyl-CoA with glycine and taurine, as catalysed by the soluble fraction from guinea-pig liver, had ...