Obesity has reached epidemic proportions and is associated with chronic-low-grade inflammation metabolic morbidities. Energy-dense diets a sedentary lifestyle are determinants of obesity. The gut microbiome novel biological factor involved in obesity via interactions the host diet. act as synergistic force protecting or aggravating effects diet on phenotype. role regulation intestinal systemic ...

Take a moment to consider that there are ten times more bacteria present in the human gut than there are human cells in the body. Surprising and shocking as this may be, it should also occur to you that such vast numbers of bacteria are not there just by chance. In fact, these populations play numerous vital roles in our health and daily functioning. There are at least 100 trillion bacterial ce...

Alcohol-induced liver injury poses a significant threat to human health. Probiotics have been proven prevent and treat alcohol-induced injury. In this study, the preventive effect of Bifidobacterium lactis TY-S01 on in mice was investigated. pretreatment effectively protected against by preserving levels alanine aminotransferase, aspartate alkaline phosphatase, triglyceride high-density lipopro...

Current research emphasizes the contribution of gut microbiome to numerous health conditions includingcancer and skeletomuscular disorders. Cachexia is a debilitating condition progressive loss bodytissues. It occurs in up 80% patients with tumors, it impairs their functioning quality life andincreases morbidity premature death. Several randomized trials indicate that interventions, which targe...

Bariatric surgeries are hypothesized to produce weight loss and improve diabetes control by multiple mechanisms including gastric restriction and lower gut stimulation; the relative importance of these mechanisms remains poorly understood. We compared the effects of a typical foregut procedure, sleeve gastrectomy, (SG) with a primarily hindgut surgery, ileal transposition (IT), alone and togeth...

We asked whether crystalloid administration improves tissue oxygen extraction in endotoxicosis. Four groups of anesthetized pigs (n = 8/group) received either normal saline infusion or no saline and either endotoxin or no endotoxin. We measured whole body (WB) and gut oxygen delivery and consumption during hemorrhage to determine the critical oxygen extraction ratio (ERO2 crit). Just after onse...

The aetiology of rheumatoid arthritis (RA) remains unknown. The involvement of the gut in reactive arthritis (ReA) and of the genitourinary system in Reiter's syndrome (RS), though recognised, is poorly understood. Distribution of phlogistic products via Batson's plexus has been suggested to account for the distribution of involved joints in these conditions.' Ankylosing spondylitis (AS) too ha...

Important protective roles of intestinal alkaline phosphatase (IAP)--including regulation of intestinal surface pH, absorption of lipids, detoxification of free nucleotides and bacterial lipopolysaccharide, attenuation of intestinal inflammation, and possible modulation of the gut microbiota--have been reviewed recently. IAP is modulated by numerous nutritional factors. The present review highl...

Preterm neonates have an immature gut and metabolism and may benefit from total parenteral nutrition (TPN) before enteral food is introduced. Conversely, delayed enteral feeding may inhibit gut maturation and sensitize to necrotizing enterocolitis (NEC). Intestinal mass and NEC lesions were first recorded in preterm pigs fed enterally (porcine colostrum, bovine colostrum, or formula for 20-40 h...

Bronchus-associated lymphoid tissue has major morphologic and functional similarities to Peyer's patches found in the gut. Both possess a lymphoepithelium with selective antigen sampling properties, both appear in the apparent absence of direct antigen stimulation, both contain a high percentage of cells bearing IgA sdurface immunoglobulin and both can repopulate the bronchial and gut lamina pr...