In 1866 Korber found chemical differences between haemoglobin obtained from human placental blood and that from normal adult blood. Since then it has been clearly demonstrated that there are many important differences between human and animal and between foetal and adult haemoglobins (Kroger, 1888; Bischoff and Schulte, 1926; Haurowitz, 1930, 1935; Trought, 1932; Brinkman, Wildschut and Witterm...

During a routine study of the parents of a 3month-old Jamaican child with the sickle-cell trait the father was found to have a haemoglobin electrophoretic pattern identical to that of homozygous sickle-cell disease. Because he was perfectly well and had no haematological abnormalities detailed studies of his haemoglobin constitution were undertaken. These indicate that he is heterozygous for bo...

The naturally occurring polyamine spermine induces haemoglobin synthesis in murine erythroleukaemia (MEL) cells. Haemoglobin production was accompanied by accumulation of cytoplasmic beta-globin mRNA and growth inhibition, but not by cell-cycle block or changes in cell volume. Hexamethylene-bisacetamide (HMBA), a well known differentiating agent, also induces haemoglobin production, but causes ...