BACKGROUND People whose chronic pain limits their independence are especially likely to become anxious and depressed. Mindfulness training has shown promise for stress-related disorders. METHODS Chronic pain patients who complained of anxiety and depression and who scored higher than moderate in Hamilton Depression Rating Scale (HDRS) and Hospital Anxiety and Depression Scale (HADS) as well a...

OBJECTIVES To compare the efficacy and tolerability of Hypericum perforatum (St John's wort extract) with imipramine in patients with mild to moderate depression. DESIGN Randomised, multicentre, double blind, parallel group trial. SETTING 40 outpatient clinics in Germany. PARTICIPANTS 324 outpatients with mild to moderate depression. INTERVENTION 75 mg imipramine twice daily or 250 mg h...

Data Extraction: Children’s Depression Rating Scale– Revised scores (youth population), Hamilton Depression Rating Scale scores (adult and geriatric populations), and estimated response and remission rates at 6 weeks were analyzed for 2635 adults, 960 geriatric patients, and 708 youths receiving fluoxetine and for 2421 adults receiving immediate-release venlafaxine and 2461 adults receiving ext...

OBJECTIVE There have been few placebo-controlled trials of selective serotonin reuptake inhibitors for depressed elderly patients. This placebo-controlled study of sertraline was designed to confirm the results of non-placebo-controlled trials. METHOD The subjects were outpatients age 60 years or older who had a DSM-IV diagnosis of major depressive disorder and a total score on the 17-item Ha...

BACKGROUND AND PURPOSE Assessing poststroke depression may be complicated by aphasia, other cognitive deficits, and several somatic stroke-related symptoms. We studied the possible differences in performance of some commonly used instruments in screening depression after stroke. METHODS We compared the Beck Depression Inventory, Hamilton Rating Scale for Depression, Visual Analogue Mood Scale...

BACKGROUND The influence of ethnicity on different aspects of psychiatric hospitalization is far from clear. THE AIM OF THE STUDY The main aim of the study was to compare the Arab and the Jewish inpatients, at the time of admission, for the demographic factors, severity of psychotic, and affective psychopathology and comorbid drug abuse rate. POPULATION, METHOD, AND TOOLS: Among 250 consecuti...

The completion of three recent large-scale, double-blind controlled acute trials in bipolar I depression has improved our understanding of the management of major depressive episodes associated with bipolar disorder. In contrast to the cross-over designs used in the early studies of lithium in bipolar depression, the designs utilized in these recent studies have employed random assignment to pa...

OBJECTIVE To study the long-term effects of deep brain stimulation (DBS) of the bilateral subthalamic nucleus (STN) on depression in patients with Parkinson's disease (PD) and to discuss the mechanism. METHODS A STN-DBS group (n = 27) and anti-Parkinson's medication control group with paired designing were set up. The evaluation of the depression and motor function was performed a total of si...

Introduction: Patients with cancer may have many complications involving their psychosomatic systems, such as sleep disturbance, depression, and anxiety. Thus, many research studies were conducted to reduce these complications. Zolpidem, as a short-term non-benzodiazepine treatment of insomnia, and melatonin as a chronobiological function-regulatory hormone, are commonly used for improving slee...

Data were evaluated from a pilot phase 2 clinical trial (N=55) with a new antidepressant and multivariate discriminant analysis (PROC DISCRIM) was used to separate the drug-treated from placebo populations by treatment subgroups. The list of variables for discriminant analysis included the percent of change from baseline for the primary efficacy variable (21-item Hamilton Depression Rating Scal...