BACKGROUND Recent studies show that the haptoglobin phenotype in individuals with diabetes mellitus is an important factor for predicting the risk of myocardial infarction, cardiovascular death, and stroke. Current methods for haptoglobin phenotyping include PCR and gel electrophoresis. A need exists for a reliable method for high-throughput clinical applications. Mass spectrometry (MS) can in ...

BACKGROUND Haptoglobin (Hp) alpha-chain alleles 1 and 2 account for 3 phenotypes that may influence the course of inflammatory diseases via biologically important differences in their antioxidant, scavenging, and immunomodulatory properties. Hp1-1 genotype results in the production of small dimeric, Hp2-1 linear, and Hp2-2 cyclic polymeric haptoglobin molecules. We investigated the haptoglobin ...

OBJECTIVE Antioxidant trials have not demonstrated efficacy in slowing cardiovascular disease but could not rule out benefit for specific patient subgroups. Antioxidant therapy reduces LDL oxidizability in haptoglobin 1 allele homozygotes (Hp 1-1), but not in individuals with the haptoglobin 2 allele (Hp 2-1 or Hp 2-2). We therefore hypothesized that haptoglobin type would be predictive of the ...

Haptoglobin exerts renal protective function by scavenging free hemoglobin from the urine and blood stream in patients with hemolytic disorders. Recent studies elucidate the relationships between haptoglobin and inflammation. In addition, coagulopathy is often induced by systemic inflammation characterized by the presence of vascular endothelial damage. We hypothesize that haptoglobin might hav...

toglobin was determined by the method of Ratcliff and Hardwicke (6). Serum haptoglobin concentration in the normal controls was 1439 ± 405 mg/liter; in the cases of pure iron deficiency it was 798 ± 323 mg/liter. In the cord sera the concentration of haptoglobin was 195 ± 112 mg/liter. The patients’ values for serum haptoglobin were clearly (P <0.001) lower than those of normal controls. It is ...

blood samples were collected from the jugular vein of 101 clinically healthy iranian fat-tailed sheep according to their age (5 years) and sex. serum haptoglobin (hp) was measured based upon the preservation of the peroxidase activity of haemoglobin, which is directly proportional to the amount of hp. the reference value for serum hp of apparently healthy iranian fat-tailed sheep was 0.05-0.18 ...

Background: Allergic rhinitis (AR) is an allergic disorder of the nasal tissue that underlies diseases such as sinusitis, otits and asthma. Different predisposing factors including immunological and non-immunological factors contribute to the disease pathogenesis. Objective: To investigate association of haptoglobin (Hp) phenotypes (Hp1-1, 2-1 and 2-2) with serum immunoglobulins A and E levels ...