Purpose To report a young patient who initially manifested with bilateral anterior nodular scleritis and subsequently developed ocular features typical of Vogt-Koyanagi-Harada (VKH) disease. Case description A 9-year-old girl was diagnosed with bilateral anterior nodular scleritis, which improved with topical administration of corticosteroids and systemic nonsteroidal anti-infl ammatory drugs. ...

Background: First recognized at the beginning of twentieth century and named after three authors who independently described some affected patients, Vogt-Koyanagi-Harada syndrome is a rare multisystemic autoimmune disease targeting melanin-containing tissues of the eye, meninges, inner ear and skin. It predominantly affects Asian people, but also people with darker skin pigmentation such as Nat...

The nuclear polyhedrosis virus of Autographa californica has been titrated in Spodoptera frugiperda cells by the plaque method, using a solid overlay which does not require either the use of modified culture medium or expensive purified agarose or the addition of culture medium as a liquid layer above the solid agarose. This assay is more sensitive than that using a viscous methyl cellulose ove...

Bombyx spermatogonia are bipotential, producing nucleate eupyrene sperm and anucleate apyrene sperm. An in vitro cultivation of spermatocysts of Bombyx mori from spermatocytes to matured sperm was established. The present experiment made clear that: (i) spermatocysts must be isolated; (ii) constant shaking at 45 r.p.m. was necessary; and (iii) the addition of Bombyx hemolymph (BH) was indispens...

Plasma uric acid (UA) levels decrease following clinical progression and stage development of Parkinson's disease (PD). However, the molecular mechanisms underlying decreases in plasma UA levels remain unclear, and the potential to apply mutagenesis to a PD model has not previously been discovered. We identified a unique mutant of the silkworm Bombyx mori (B.mori) op. Initially, we investigated...

In this paper we study the birational rigidity problem for smooth Mori fibrations on del Pezzo surfaces of degree 1 and 2. For degree 1 we obtain a complete description of rigid and non-rigid cases. 1. Notions and results. Due to progress in the Minimal Model Program, the classification problem in the modern birational geometry for varieties of negative Kodaira dimension can be formulated as fo...