Harlequin ichthyosis (HI) is a rare autosomal recessive congenital with an incidence of 1 in 300,000 live births. It lethal 44% cases and the baby usually prematurely born. These babies have thick, highly keratinized armor-like skin, which forms large diamond, trapezoid or rectangular plates separated by deep fissures. affect shapes eyelids, nose, mouth ears, also limit movement arms, legs ches...
