The paper studies the effect of RVI biocomposite material belonging to group osteoplastic materials, RV-2 immunomodulator – a synthetic dipeptide inducing an immunocorrective effect, and combinations these drugs on reparative histogenesis bone tissue in femoral fractures rats. It was found that remodeling primary callus into secondary one fracture studied animals diverse nature. This process mo...

The common wombat (Vombatus ursinus) is equipped with a set of physiological and morphological adaptations suited to fossorial lifestyle. These allow wombats engage in efficient scratch-digging maintaining low basal metabolic rate while living underground. While bone microstructure has been described for several subterranean animals, histology received very little attention date. Here, we prese...

Abstract Aiming to evaluate cortical bone microarchitecture and osteonal morphology after irradiation, twelve male New Zealand rabbits were used. The animals divided: control group (no radiation-NIr); 3 irradiated groups, sacrificed after: 7 (Ir7d); 14 (Ir14d) 21 (Ir21d) days. A single radiation dose of 30 Gy was Computed microtomography analyzed the microarchitecture: thickness (CtTh), volume ...

Introduction. The effect of sciatic nerve neurectomy on the loss bone density femur and tibia has been proven in experimental biological models, but condition bones distal limb parts after surgeries, aimed at innervation restoring not studied. Purpose to reveal structural changes shaft third metatarsal primary autogenous plasty resection defect tibial portion rats. Materials Methods. Autologous...

Implanted pure titanium fixtures are able to completely integrate with bone, in part because of the formation of a strong extracellular matrix (ECM) bond at the titanium-bone interface. In this study, we used a rodent femur model of intramedullary osseointegration to analyze the changes in immunoreactivity of ECM-controlling matrix metalloproteinases (MMPs), tissue inhibitor of metalloproteinas...

In this paper, the in vivo response, in particular, the histocompatibility of newly developed CaP-mullite composites is reported. In the present experiments, the bioceramic implants were inserted in the long bones of healthy rabbits according to standard protocols (ISO-10993) and the tissue response was studied at different time intervals of up to 12 weeks. Ultra high-molecular weight polyethyl...

Damage accumulation in living tissues occurs when the rate of damage formation is greater than the rate of damage repair. For very large increases in the loading rate of bones, this can result in "stress fractures" due to the growth and coalescence of fatigue related microdamage. At lower increases of loading rates, the damage accumulation process is halted because there is time for adaptive bo...

BACKGROUND AND PURPOSE Parathyroid hormone (PTH) has attracted considerable interest as a bone anabolic agent. Recently, it has been suggested that PTH can also enhance bone repair after fracture and distraction osteogenesis. We analyzed bone density and strength of the newly regenerated mineralized tissue after intermittent treatment with PTH in rabbits, which undergo Haversian bone remodeling...