OBJECTIVE Epidemiological studies have shown an association between OA and increased BMD. To explore the nature of this relationship, we examined whether the risk of OA is increased in individuals with high bone mass (HBM), in whom BMD is assumed to be elevated due to a primary genetic cause. METHODS A total of 335,115 DXA scans were screened to identify HBM index cases (defined by DXA scan a...

Production of human mesenchymal stem cells for allogeneic cell therapies requires scalable, cost-effective manufacturing processes. Microcarriers enable the culture of anchorage-dependent cells in stirred-tank bioreactors. However, no robust, transferable methodology for microcarrier selection exists, with studies providing little or no reason explaining why a microcarrier was employed. We syst...

Emerging workloads in cloud and data center infrastructures demand high main memory bandwidth capacity. Unfortunately, DRAM alone is unable to satisfy contemporary demands. High-bandwidth (HBM) uses 3D die-stacking deliver 4–8× higher bandwidth. HBM has two drawbacks: (1) capacity low, (2) soft error rate high. Hybrid combines promise low fault rates, bandwidth, Prior OS approaches manage by ma...

The emergence of transformer models like BERT means that deep learning language can achieve reasonably good performance in document classification with few labelled instances. However, there is a lack evidence for the utility applying BERT-like on long few-shot scenarios. This paper introduces long-text-specific model—the Hierarchical Model (HBM)—that learns sentence-level features and works we...

Abstract Presented herein is a novel design framework for obtaining the optimal of functionally graded lattice (FGL) structures that involve using physical discrete structural model called Hencky bar-grid (HBM) and topology optimization (TO). The continuous FGL structure discretized by HBM comprising rigid bars, frictionless hinges, pulleys, elastic primary secondary axial springs, torsional sp...

This article assesses two Harmonic Balance Method-based numerical Lagrangian strategies for the characterization of periodic response a mechanical system subject to unilateral contact constraints. The model used evaluation is an academic rod facing obstacle that firstly considered as equivalent stiffness (flexible) and then rigid obstacle. Nonlinear frequency curves are obtained through arc-len...

Resting-state functional magnetic resonance imaging (rs-fMRI) offers the opportunity to noninvasively study brain networks within individuals. Previous individual-specific network mappings do not account for intra-subject (within-subject) variability. Therefore, intrasubject variability might be mistaken for inter-subject (between-subject) differences. Here we propose a multi-session hierarchic...