Introduction: The objective of this work was to investigate the therapeutic effect of a combination of hyperthermia at 43oC exposured for 20, 40, 60 min with 6MeV electron beams at different radiation doses (2, 4, 6 Gy) compared to radiation alone.   Materials and Methods: In this in vitro study, HeLa cells were exposed to either: 6MeV electron beams at diffe...

Purpose: To delve into the related molecular mechanism of suppressor cytokine signaling 4 (SOCS4) on cervical cancer cell proliferation and migration. Methods: Quantitative real-time polymerase chain reaction western blot assays were employed to examine SOCS4 mRNA or protein expression in four human line (HeLa, SW-732, AV3, CaSki) normal epithelium immortalized (H8) MTT viability applied verify...

• Quinoline-based BODIPYs as potential EGFR/VEGFR-2 inhibitors. Lipinski's drug likeness of compounds 1–3 revealed promising physicochemical properties for oral bioavailability. The interaction was examined by molecular docking with binding energies in the order 3˃2˃1. HOMO and LUMO were also calculated using DFT method. vitro anticancer activity 1 3 on HeLa cells evaluated. This paper reports ...

Background: Flavonoids have a variety of biological activities, such as anti-allergic, anti-inflammatory, anti-oxidative, free radical scavenging, and anti-mutagenic. Methods: The cytotoxic effects of three synthesized flavonoid derivatives (K3, K4 and K5) were evaluated against Hela , MDA-MB -231 and HT-29 cancer cells using MTT assay. Results: The results showed that these flavonoids were n...

Curcumin is the natural bio-active component of turmeric (Curcuma longa L.) with known therapeutic properties; nevertheless, its biological applications are limited due to its poor bioavailability. To overcome this limitation, curcumin was conjugated with silica nanoparticles. Curcumin was separated from turmeric by microwave-assisted extraction and silica nanoparticles were developed from rice...

The ability to isolate rhinoviruses in human heteroploid cell cultures was investigated by inoculating HeLa cells (HeLa M) with specimens previously shown to be positive in human diploid cell cultures. The 135 positive specimens selected were representative of 22 different rhinovirus types, and 4 to 9 specimens were available for each serotype. Specimens were inoculated into human diploid fetal...

OBJECTIVE Paclitaxel is one of the common anticancer drugs in the treatment of cervical cancer, while the mechanism of restraining and killing cancer cells is still unclear. This study aimed to investigate the molecular mechanism of paclitaxel in regulating proliferation and apoptosis of cervical cancer Hela cells. MATERIALS AND METHODS Paclitaxel at 2 μmol/L was used to treat Hela cells for ...