نتایج جستجو برای: hematologic
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I. HODGKIN’S LYMPHOMA A. Presentation 1. Subjective. Classical Hodgkin’s disease or Hodgkin’s lymphoma (HL) usually presents as painless lymphadenopathy in the cervical and/or supraclavicular regions. Isolated subdiaphragmatic lymphadenopathy or organ involvement is rare. Although staging studies reveal mediastinal adenopathy in more than 85% of patients, symptoms of cough, chest pain, dyspnea,...
The bromodomain and extra-terminal (BET) family of proteins are important epigenetic regulators involved in promoting gene expression of critical oncogenes. BET inhibitors have been demonstrated to repress c-Myc expression, and were initially shown to have efficacy in a number of c-Myc-dependent hematologic malignancies. Recent studies have now revealed a broader role for BET inhibitors in hema...
BACKGROUND The incidence of hematologic cancers increases with age. These cancers are associated with recurrent somatic mutations in specific genes. We hypothesized that such mutations would be detectable in the blood of some persons who are not known to have hematologic disorders. METHODS We analyzed whole-exome sequencing data from DNA in the peripheral-blood cells of 17,182 persons who wer...
Hematologic malignancies complicating pregnancy are uncommon, but a delay in diagnosis or treatment can mean the difference between life and death. It is the responsibility of the obstetrician, nurse-midwife, or nurse practitioner to maintain a high index of suspicion when patients present with unexplained lymphadenopathy or protracted constitutional symptoms. Management of these patients requi...
(58 articles) Reviews in Translational Hematology (4217 articles) Neoplasia (149 articles) Genomics (1086 articles) Gene Expression Articles on similar topics can be found in the following Blood collections http://bloodjournal.hematologylibrary.org/site/misc/rights.xhtml#repub_requests Information about reproducing this article in parts or in its entirety may be found online at: htt...
BACKGROUND AND OBJECTIVES To evaluate the clinical characteristics of patients affected by hematologic malignancies who developed mucormycosis and to ascertain the factors which influenced the outcome following mycotic infection. DESIGN AND METHODS This was a retrospective study conducted over a 15-year period (1987-2001). The study included 59 patients with hematologic malignancies with a pr...
Granulocytic sarcomas are rare tumors composed of neoplastic blood cells, typically occurring during the course of acute nonlymphoblastic leukemia or before its onset. We present a case of a 23-year-old young adult man with metachronous granulocytic sarcoma of the testis without hematologic manifestations who was diagnosed with granulocytic sarcoma (GS). The patient was treated with right orchi...
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