Objective: The bone marrow is the primary site for blood cell formation, responsible production and export of red cells, platelets, granulocytes. Pancytopenia a condition characterized by reduction in all three types cellular components peripheral blood, leading to symptoms failure. management prognosis pancytopenia depend on identifying underlying pathology.
 Methods: pathophysiology invo...

The renin-angiotensin system (RAS) has long been a known endocrine system that is involved in regulation of blood pressure and fluid balance. Over the last two decades, evidence has accrued that shows that there are local RAS that can affect cellular activity, tissue injury, and tissue regeneration. There are locally active ligand peptides, mediators, receptors, and signaling pathways of the RA...

This study examines the long-term effects of SARS-CoV-2 infection on immune status. Given prolonged and profound dysregulation observed during acute infection, it remains to be determined whether these changes translate into subsequent system dysfunction in recovering individuals. In this sense, aim was parameters patients who had undergone infection. 150 underwent were examined according 96 us...

BACKGROUND Reduction of intramedullary hematopoiesis and the development of myelofibrosis and splenic hematopoiesis are frequent complications of clonal myeloid disorders that cause severe morbidity and death and present a therapeutic challenge. However, the pathogenesis of these complications is still unknown. We evaluated the effect of fibroblast growth factor 2 (FGF-2), the level of which is...

BACKGROUND AND OBJECTIVE The myelodysplastic syndromes comprise a heterogeneous group of neoplastic disorders characterized by ineffective hematopoiesis with an increased tendency to evolve to acute leukemia. Clinically, the common manifestations include peripheral blood cytopenias of one or more lineages and a normal to hyperplastic marrow. MDS has been defined on the basis of morphological cr...