نتایج جستجو برای: hemiplegic migraine
تعداد نتایج: 14930 فیلتر نتایج به سال:
OBJECTIVE The CACNA1A gene encodes the pore-forming subunit of neuronal Ca(V)2.1 Ca2+ channels. In patients, the S218L CACNA1A mutation causes a dramatic hemiplegic migraine syndrome that is associated with ataxia, seizures, and severe, sometimes fatal, brain edema often triggered by only a mild head trauma. METHODS We introduced the S218L mutation into the mouse Cacna1a gene and studied the ...
Mutations in alpha1A, the pore-forming subunit of P/Q-type calcium channels, are linked to several human diseases, including familial hemiplegic migraine (FHM). We introduced the four missense mutations linked to FHM into human alpha1A-2 subunits and investigated their functional consequences after expression in human embryonic kidney 293 cells. By combining single-channel and whole-cell patch-...
Cerveau et de L’Œil, Groupe Hospitalier Lariboisière – Fernand Widal, Paris, France ; 5 INSERM UMR_S 740, Université Paris Diderot, Sorbonne Paris Cité, Paris 6 Service de Neurologie, CHU de Limoges, Hôpital Dupuytren, Limoges, France; 7 Service de Cardiologie, CHU de Limoges, Hôpital Dupuytren, Limoges, France; 8 Unité Mixte de Recherche en Santé (UMR_S956), Université Pierre & Marie Curie (UP...
Migraine is a common neurological disorder that affects 11% of adults worldwide. This disease most likely has a neurovascular origin. Migraine with aura (MA) and more common form - migraine without aura (MO) - are the two main clinical subtypes of disease. The exact pathomechanism of migraine is still unknown, but it is thought that both genetic and environmental factors are involved in this pa...
Stroke mimics, like attacks of hemiplegic migraine, are challenging in acute stroke evaluation. We present a 28-year-old woman with a suspected hemiplegic migraine attack with left-sided hemiparalysis. Brain CT with perfusion imaging 1 h 54 min after symptom onset revealed hypoperfusion in the right hemisphere. The patient was treated with intravenous recombinant tissue plasminogen activator (r...
BACKGROUND Episodic ataxia type 2 (EA2) and familial hemiplegic migraine type 1 (FHM1) are autosomal dominant disorders characterised by paroxysmal ataxia and migraine, respectively. Point mutations in CACNA1A, which encodes the neuronal P/Q-type calcium channel, have been detected in many cases of EA2 and FHM1. The genetic basis of typical cases without CACNA1A point mutations is not fully kno...
FHM3 is a rare subtype of familial hemiplegic migraine (FHM) caused by mutations in the neuronal sodium channel gene SCN1A (1). Only five FHM3 mutations have been described in a few families since the identification of SCN1A as the third FHM gene in 2005 (1–4). In the present issue of Cephalalgia, Weller et al. (5) report the identification of two novel SCN1A FHM3 mutations in two families with...
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