BACKGROUND Interleukin-17A is the signature cytokine of the Th17 subset and drives inflammatory pathology, but its relevance to autoantibody-mediated diseases is unclear. Th1 cells secreting interferon-γ have been implicated in autoimmune hemolytic anemia, so the aim was to determine which cytokine is more closely associated with disease severity. DESIGN AND METHODS Interferon-γ and interleuk...

Introduction Early diagnosis of atypical uremic-hemolytic syndrome may be challenging during the puerperium period. Correct diagnosis and timely management are crucial to improve outcomes. Background Pregnancy-associated atypical hemolytic-uremic syndrome (p-aHUS) is a rare condition characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury. Triggered by preg...

Autoimmune hemolytic anemia is a heterogeneous disease with respect to the type of the antibody involved and the absence or presence of an underlying condition. Treatment decisions should be based on careful diagnostic evaluation. Primary warm antibody autoimmune hemolytic anemias respond well to steroids, but most patients remain steroid-dependent, and many require second-line treatment. Curre...

BACKGROUND Autoimmune hemolytic anemia is rare in children. First-line therapies for this disease consist of corticosteroids and intravenously administered immunoglobulin that are effective in most patients. However, a small proportion of cases (5 to 10%) is refractory to these therapies and may represent a medical emergency, especially when hemolysis is due to warm immunoglobulin M. Recently, ...

haemovigilance is a system with standard program to cover the entire transfusion chain, monitor, evaluate and analyse the data to improve patients’ safety. we report the implemented haemovigilance system in hospitals and transfusion reactions (tr) in iran. methods and materials: this was a prospective descriptive study. the national reporting system for transfusion incidents was introduced in j...

By MARY B. COOPER, B.A., M.T. (ASCP) I N 1909, Buchan and Comrie” reported the occurrence of erythrophagocytes in the peripheral blood of 2. newborn infants with ‘ ‘congenital anemia and enlargement of the spleen. ‘ ‘ In 193 I , Abt2 described these cells in blood smears of a case of anemia of the newborn. In 1938, Wyatt, Cooper and Groat9 reported 3 cases of the same disease in which the cells...