Given the significance of carbohydrates in life, medicine, and industry, the development of simple and efficient de novo methods to synthesize carbohydrates are highly desirable. Organocatalytic asymmetric assembly reactions are powerful tools to rapidly construct molecules with stereochemical complexity from simple precursors. Here, we present a simple and robust methodology for the asymmetric...

Henry VIII’s legacy Henry VII was definitely a medieval king, which Henry VIII was determined not to be. Sophisticated and learned Europe was said to be 100 years in advance of England, which was still clinging to the old ways. The “green and sceptred isle” was not attractive to the artists and philosophers who had found a rich and glittering haven in other courts. The eighth Henry was a handso...

BACKGROUND Family-based interventions to prevent childhood obesity depend upon parents' taking action to improve diet and other lifestyle behaviours in their families. Programmes that attract and retain high numbers of parents provide an enhanced opportunity to improve public health and are also likely to be more cost-effective than those that do not. We have developed a theory-informed optimis...

From the Oxygen Sensing Group, The Henry Wellcome Building for Molecular Physiology, University of Oxford, Oxford OX3 7BN and Genomics Group, Wellcome Trust Centre for Human Genetics, The Henry Wellcome Building for Genomic Medicine, University of Oxford, Oxford, OX3 7BN Running title: Hypoxic gene regulation and 2-OG dependent dioxygenases * Address correspondence to: The Henry Wellcome Buildi...