The ability of heparin to dramatically enhance the inactivation of thrombin (IIa) by antithrombin III (ATIII) in buffer is negated through formation of a IIa-fibrin-heparin ternary complex (Hogg and Jackson, Proc Natl Acad Sci USA 86:3619, 1989; Hogg and Jackson, J Biol Chem 265:241, 1990). IIa, in this ternary complex, is protected from inactivation by ATIII. Our aim was to determine whether f...

Abstract Background and Aims During hemodialysis exposure of the blood to dialysis membrane tubing system can activate cells promote clotting activation. So usually, some form anticoagulation, most frequently heparin, is used prevent coagulation. However, there are patients with increased risk for bleeding (patients active bleeding, major surgery in past 72 hours, severe trombocytopenia) where ...

Evidence is presented that heparin pretreatment produces protective effects on myocardial tissue distinct from its anticoagulant activity. The present study examines the ability of heparin sulfate and N-acetyl heparin (a derivative of heparin devoid of anticoagulant effects) to protect the heart from injury associated with global ischemia and reperfusion. Male New Zealand White rabbits were adm...

Background: Spontaneous heparin-induced thrombocytopenia is a pro-thrombotic syndrome in which anti-heparin antibodies develop without heparin exposure. Case presentation: A 78-year-old man who underwent successful lumbar laminectomy presented to the hospital 5 days after discharge for stroke-like symptoms and was found have acute infarcts of bilateral frontal lobes. The patient be severely thr...

Mục tiêu nghiên cứu: Nhận xét một số biến chứng liên quan đến rối loạn đông máu ở bệnh nhân sử dụng Heparin trong kỹ thuật tim phổi tạo. Đối tượng và phương pháp 67 ECMO từ tháng 9 năm 2019 2020 tại Bệnh viện Bạch Mai được chống là Heparin. Kết quả Tỷ lệ nữ giới chiếm chủ yếu với 61.2%. Viêm cơ nhóm tỷ cao nhất 38.8%. Gặp các như sau: Xuất huyết lớn (10.7%), xuất nhỏ (76,1%), khối (7.4%), không...

Vitronectin is a 70-kDa protein that is found in both the extracellular matrix as well as serum. Vitronectin is one of the few proteins that regulates both the complement and the coagulation systems. Heparin is known to bind to vitronectin. Review of the literature reveals apparently conflicting outcomes of the interaction of heparin, vitronectin, and the complement system. Previous studies dem...

BACKGROUND The clinical benefits of heparin reach beyond its anticoagulative properties. Recently, it has been described that leukocytes adhere on immobilized heparin mediated by the integrin Mac-1 (CD11b/CD18, alphaMbeta2, or CR3). Because inhibition of this versatile adhesion molecule could explain various aspects of the beneficial clinical effects of heparin, we evaluated whether soluble hep...

The specificity of endothelial binding sites for heparin was investigated with heparin fractions and fragments differing in their Mr, charge density and affinity for antithrombin III, as well as with heparinoids and other anionic polyelectrolytes (polystyrene sulphonates). The affinity for endothelial cells was estimated by determining I50 values in competition experiments with 125I-heparin. We...