Hepatitis E is endemic in many developing countries where it causes substantial morbidity. In industrialised countries, it is considered rare, and largely confined to travellers returning from endemic areas. However, there is now a growing body of evidence that challenges this notion. Autochthonous hepatitis E in developed countries is far more common than previously recognised, and might be mo...

background little is known about hev seroprevalence and its determinants in iran. considering the fact that iran is among the countries in which hev infection is endemic, a large-scale population-based study in this regard is justified. methods this survey was conducted in 2006 in tehran and golestan provinces, iran. stored sera of subjects were tested for serological markers of anti-hev. the b...

results the mean age of pregnant women was 27.2 ± 5.6 years. the overall seroprevalence of anti-hev was 7.4%. there was a significant association between anti-hev seropositivity and age (p < 0.001), degree of education (p = 0.017), number of household members (p = 0.002), siblings (p = 0.005), and parities (p = 0.007). however, no significant relationship was observed between positive anti-hev ...

dna coding for the core antigen from hepatitis b virus (hbcag) was amplified, cloned and propagated in e. coli. the core protein was expressed in e. coli and the product was readily detected by western blot. this protein can be used as a diagnostic material in serum screening tests. to increase the level of expression of this antigen in bacteria, two plasmids were constructed in which the gene ...

Burden of Viral Hepatitis on Human Health Compared to better-publicized infectious diseases such as HIV or malaria, viral hepatitis is often referred to as a silent killer. • Of the five hepatitis viruses (A-E), hepatitis B, C, and D viruses cause chronic liver disease leading to cirrhosis, liver failure and liver cancer. Hepatitis B, C and D viruses, transmitted through blood and body fluids, ...

BACKGROUND & AIMS Fulminant hepatitis is a rare outcome of infection with hepatitis E virus. Several recent reports suggest that virus variation is an important determinant of disease progression. To critically examine the evidence that virus-specific factors underlie the development of fulminant hepatitis following hepatitis E virus infection. METHODS Published sequence information of hepati...

conclusions fluctuations in serum alt levels may change the prognosis of a hbv inactive carrier state. objectives this study aimed to determine the incidence rate and patterns of alt fluctuations and prognostic values for the development of chronic hbv e antigen (hbeag)-negative hepatitis b (chb), hbv surface antigen (hbsag) seroclearance, and liver-related complications. patients and methods t...

conclusions in hbeag positive chb patients, low serum hbsag level is a useful predictor of compensated cirrhosis. objectives the aim of our study was to evaluate serum hbsag level as a biomarker for compensated cirrhosis in hepatitis b e antigen (hbeag) positive chb patients. patients and methods two-hundred and one hbeag-positive chinese chb patients with or without cirrhosis were enrolled in ...

‎Hepatitis B virus (HBV) infection is a major public health problem in the world today‎. ‎A mathematical model is formulated to describe the spread of hepatitis B‎, ‎which can be controlled by vaccination as well as treatment‎. ‎We study the dynamical behavior of the system with fixed control for both vaccination and treatment‎. ‎The results shows that the dynamics of the model is completely de...