conclusions serum stnfr-iiα could be used as a potential serum marker in diagnosing hcc among patients with hcv infection. results the serum level of stnfr-iiα was significantly higher in patients with hcc in comparison to the other groups. a positive correlation was found between the serum levels of stnfr-iiα and ast and alt in patients of group-ii. diagnosis of hcc among patients with hcv inf...

background : data mining has an interdisciplinary field including various scientific disciplines such as: database systems, statistics, machine learning, artificial intelligence and the others. in the field of medical, data mining algorithms can help physicians to diagnose diseases and chose the best type of treatment. hepatocellular carcinoma has the most common type of liver cancer. given the...

Aberrant activation of the Notch signaling pathway is implicated in many solid tumors, including hepatocellular carcinoma, indicating a potential use of Notch inhibitors for treatment. In this study, we investigated the antitumor and antimetastasis efficacy of the novel Notch inhibitor (γ-secretase inhibitor) PF-03084014 in hepatocellular carcinoma. Hepatocellular carcinoma spherical cells (ste...

Twelve hepatocellular nodules were characterized in the resected livers from 3 patients (2 men and a woman) with alcoholic cirrhosis. Imaging techniques suggested that the nodules were hypervascular and may be hepatocellular carcinoma. Five nodules (4-31 mm in diameter) were serum amyloid A-positive hepatocellular neoplasm, which shares features with inflammatory hepatocellular adenoma. The rem...

INTRODUCTION Hepatocellular carcinoma is an aggressive malignant tumor with high lethality. AIM To review diagnosis and management of hepatocellular carcinoma. METHODS Literature review using web databases Medline/PubMed. RESULTS Hepatocellular carcinoma is a common complication of hepatic cirrhosis. Chronic viral hepatitis B and C also constitute as risk factors for its development. In p...

Cell suspensions of tumor fragments derived from spontaneous or chemically induced primary hepatocellular carcinomas obtained from inbred C3H/HeN mice were transplanted into young male mice of the same strain. Transplantable hepatocellular carcinomas were excised as soon as they were detected, and all recipient mice were killed at one year of age. In control C3H/HeN mice, the incidence of prima...

objective: micrornas (mirnas) are single-stranded small rnas 18-25 nucleotides in length that regulate gene expression through translational inhibition and mrna cleavage. aberrant expression of mirnas contribute to several diseases. this has increased interest in profiling the expressions of these molecules. real-time quantitative pcr (rq-pcr) is a sensitive, quantitative technique for gene exp...

background and objectives: colorectal cancer is the third most common cancer and a major cause of morbidity globally. hepatocellular carcinoma is a leading cause of death in the world. about 80% of all anticancer drugs are somehow related to natural products. one of the most important of these natural compounds is curcumin, the main component of turmeric that has a wide range of pharmacological...

background: the association between hepatitis b virus (hbv) mutations and hepatocarcinogenesis were reported in the literature. preference for g over c in the leading dna strand has been reported to account for the asymmetry in nucleotide (nt) composition. the aim of this study was to analyze the complete genome sequence and compositional asymmetry of hbv in different stages of hepatitis b. met...