intEnDED USE The PathVysion HER-2 DNA Probe Kit (PathVysion Kit) is designed to detect amplification of the HER-2/neu gene via fluorescence in situ hybridization (FISH) in formalin-fixed, paraffin-embedded human breast cancer tissue specimens. Results from the PathVysion Kit are intended for use as an adjunct to existing clinical and pathologic information currently used as prognostic factors i...

pp. 2-4 " Next Generation Networks (NGN) " : these three words have emerged since 1998 as a leitmotiv for a number of networking industries and academic organizations. A search engine such as Google will find more than 55 millions answers referencing leading industrial projects for building NGN products, infrastructures, services and applications. There will also be a tremendous amount of techn...

1.1 erbB family HER-2 is a member of the erbB family of receptor tyrosine kinases. Epidermal Growth Factor Receptor (EGFR) was first identified as the cellular homolog of the transduced oncogene of the avian retroviruses such as avian ERythroBlastosis virus, which causes erythroleukemia and fibrosarcoma and gives rise to the family name (erbB). EGFR, as its name implies, was shown by Stanley Co...

Introduction: The presence of HER-2 has been shown to be a prognostic factor in many kinds of cancers, but its role in head and neck squamous cell carcinoma (HNSCC) is not still defined. The purpose of the current study is to investigate the role of HER-2 in HNSCC and its correlation with various clinicopathologic parameters.   Materials and Methods: Peripheral blood samples were obtained ...