Background Hereditary non-polyposis colorectal cancer (HNPCC) is a hereditary cancer syndrome in which confirmed carriers of a gene mutation are at high risk for colorectal (CRC) and extracolonic cancers. The purpose of the current study was to develop a greater understanding of the factors influencing the decision-making of confirmed HNPCC carriers post-genetic testing about screening and dise...

Let R be a left pure semisimple ring such that there are no nonzero homomorphisms from preinjective modules to non-preinjective indecomposable modules in R-mod, and let W be the left key R-module; i.e., W is the direct sum of all non-isomorphic non-preinjective indecomposable direct summands of products of preinjective left R-modules. We show that if the module W is endofinite, then R is a ring...

UNLABELLED Hereditary syndromes are responsible for 10 % of gynaecologic cancers, among which hereditary breast-ovarian cancer and hereditary non-polyposis colon cancer syndromes, known as HBOC and Lynch syndromes respectively, present the highest relative risk. The latter predisposes to endometrial cancer and both contribute to ovarian cancer. Cowden syndrome-related endometrial cancer and the...

An additive induced-hereditary property of graphs is any class of finite simple graphs which is closed under isomorphisms, disjoint unions and induced subgraphs. The set of all additive induced-hereditary properties of graphs, partially ordered by set inclusion, forms a completely distributive lattice. We introduce the notion of the join-decomposability number of a property and then we prove th...

background and objectives: hereditary nonpolyposis colorectal cancer (hnpcc) is an autosomal dominant cancer predisposition syndrome caused by germ-line mutations in dna mismatch repair genes. tumors arising as a result of these mutations display instability in a sequence area known as microsatellites. studies have shown that some bethesda markers (bat25, bat26) are more efficient than others i...

the hereditary ataxias comprise a wide spectrum of heterogeneous disorders that share three features: ataxia, involvement of cerebellum or its connections, and heritability. in many hereditary ataxias, the underlying gene mutations have been identified. knowledge of the causative mutations allows a rational classification of hereditary ataxias as autosomal recessive, autosomal dominant or mater...

angioedema is an asymmetric non-pitting oedema on face, lips, tongue and mucous membranes; any delay in diagnosis and treatment can be fatal. treatment with lisinopril as an angiotensin converting enzyme (ace) inhibitor, can be a reason of angioedema. here we report a case who developed oral-facial edema four years after using lisinopril/hydrochlorothiazide. laryngeal oedema is a main cause of ...

congenital cutis laxa is an exceptional condition. no large scale pedigree has been reported from iran. we report a family with 106 members with two members affected with cutis laxa. our cases were two patients (male and female) with pre- and postnatal growth retardation, cutis laxa, characteristic facies and other manifestations which proved that they were affected with cutis laxa. their famil...

Aggregation of diabetes and hearing loss in a family is observed in some hereditary disease. All members of the present family are affected with sensory hearing loss and diabetes mellitus. Diabetes types observed were insulin dependent diabetes mellitus (IDDM) in the proposita and the sister, non-insulin dependent diabetes mellitus (NIDDM) in the brother, and impaired glucose tolerance in the m...