Eight members of the Herpesviridae family commonly infect humans, and close to 100% of the adult population is infected with at least one of these. The five that cause the most health concerns are: herpes simplex virus (HSV) type 1 and 2, Epstein-Barr virus (EBV), cytomegalovirus (CMV), and varicella zoster virus (VZV). In addition, there are human herpes virus (HHV) types 6-8. The review start...

This contribution reports the synthesis of a poly(amide)-based dendrimer functionalized at the termini with a membrane-interacting peptide derived from the herpes simplex virus (HSV) type 1 glycoprotein H, namely gH625-644. This peptide has been shown to interact with model membranes and to inhibit viral infectivity. The peptidodendrimer inhibits both HSV-1 and HSV-2 at a very early stage of th...

The herpesvirus ubiquitin-specific protease (USP) family, whose founding member was discovered as a protease domain embedded in the large tegument protein of herpes simplex virus 1 (HSV-1), is conserved across all members of the Herpesviridae. Whether this conservation is indicative of an essential function of the enzyme in vivo has not yet been established. As reported here, USP activity is co...

It's true: the herpes virus can infect various parts of the eye, including the eyelid, cornea, and parts of the inner-eye [2]. Thankfully, you can still safely make steamy eyes with someone across with room without worry ? similar to other herpes infections, the ocular variety is transmitted through skin-to-skin contact. Although this type of infection is fairly uncommon (affecting about 50,000...

It's true: the herpes virus can infect various parts of the eye, including the eyelid, cornea, and parts of the inner-eye [2]. Thankfully, you can still safely make steamy eyes with someone across with room without worry ? similar to other herpes infections, the ocular variety is transmitted through skin-to-skin contact. Although this type of infection is fairly uncommon (affecting about 50,000...

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Toll-like receptors (TLRs) are evolutionarily conserved pathogen sensors that constitute the first line of defense in the human immune system. Herpesviruses are prevalent throughout the world and cause significant disease in the human population. Sensing of herpesviruses via TLRs has only been documented in the last 10 years and our understanding of the relationship between these sentinels of t...