Background: Epidemiologic data suggest inverse associations between citrus flavanone intake and cardiovascular disease (CVD) risk. However, insufficient randomized controlled trial data limit our understanding of the mechanisms by which flavanones and their metabolites potentially reduce cardiovascular risk factors. Objective: We examined the effects of orange juice or a dosematched hesperidin ...

In 1936 Szent-Gybrgyi and coworkers (1) described the isolation of a material which was capable of increasing capillary resistance in man, and which they called citrin or vitamin P. Subsequent work has shown that many substances have this property, and vitamin P activity has been attributed variously to flavones, flavanones, and flavonols. Higby (2) found that crude hesperidin possessed vitamin...

The influence of rootstock, maturity and extraction settings on limonin, hesperidin narirutin levels orange juice was evaluated. A liquid chromatographic method to determine limonin developed validated. linear range 0.410 61.5 µg.mL-1, with a correlation coefficient higher than 0.999. limit detection 0.144 µg.mL-1and quantification 0.363 µg; precision showed RSD≤5.0% accuracy from 92.6 100.4%. ...

The combination of Diosmin and Hesperidin can be used as capillary stabilizing and antihemorrhoidal agent. A rapid, simple, precise and cost effective and reversed-phase high performance liquid chromatography (RP-HPLC) method has been developed and validated for the simultaneous determination of Diosmin and Hesperidin in pharmaceutical formulations. Separation of both Diosmin and Hesperidin was...

In previous publications from this laboratory (1, 2), it was demonstrated that phosphorylated hesperidin acted as a potent anticoagulant when administered intravenously to rabbits. The mode of action of this material appeared to be similar to that of heparin, since only the plasma recalcification times and antithrombin titers showed significant changes, whereas the prothrombin times, antithromb...

abstractthe ability of hesperidin (hp) to form complexes with five metals; cobalt, nickel, zinc, calcium and magnesium was investigated. the complexation was studied using u.v spectroscopic titration, in methanol as well as aqueous buffer solutions (physiological conditions). potential complexes were studied by ir and nmr spectroscopy, melting point and their solubility were also evaluated. the...

Introduction: Hesperidin (HES), as the most abundant flavonoid existing in the citrus, is widely used by human daily. The radio-protective effects of Hesperidin have been confirmed in various measurement systems. This study aimed to evaluate the effects of Hesperidin on the changes in the apoptosis level and expression of apoptotic genes target (bax, bcl-2 and ration of bax/bcl-2) in the periph...