Abstract The palladium-catalysed cyclisation of propargylic electrophiles with nucleophiles represents a useful synthetic approach for the rapid construction heterocyclic building blocks. However, these reaction processes often pose number challenges due to need simultaneous control chemo-, regio- and stereoselectivity. Herein, we disclose discovery ?-amido malonates as novel bis-nucleophiles i...

A versatile and green synthetic protocol has been developed for synthesis of substituted quinazolinone spiroquinazolinone heterocycles effectively via a combined surfactant mediated system. The use Surfactant, water as reaction medium, room temperature, high yield ease purification made the process very effective ecofriendly in nature. To demonstrate wide scope Isatoic anhydride Isatin used rea...

Cobalt-catalyzed activation of methylthio-substituted N-heterocycles facilitates either cross-coupling reactions with aryl- or benzylzinc compounds or synthesis of the corresponding zinc compounds.

CuO/AB was found to be a simple and efficient catalyst for the N-arylation of a variety of nitrogen-containing heterocycles, giving the products in excellent yields.

An efficient regioselective naphthoannulation strategy able to fuse a newly formed naphthalene ring at its 1,2- and 3,4- positions to two different heterocycles has been developed.

N-heterocyclic carbenes (NHCs) have been shown to be versatile ligands for transition metal complexes. Most importantly, these ligands have an outstanding impact on many homogeneous catalysts, often outperforming more common phosphine ligands. Metal coordination to NHCs has been achieved by a variety of methods. Among these, oxidative addition is particularly attractive because of the typically...