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INTRODUCTION Similar to matrix metalloproteinases, glycosidases also play a major role in cartilage degradation. Carbohydrate cleavage products, generated by these latter enzymes, are released from degrading cartilage during arthritis. Some of the cleavage products (such as hyaluronate oligosaccharides) have been shown to bind to Toll-like receptors and provide endogenous danger signals, while ...
T here are two main reasons why natural killer T (NKT) cells fascinate immunologists. First, they exhibit a unique mélange of properties found in innate immune cells as well as the properties of conventional T cells, part of adaptive immunity (1–4). Second, NKT cells exercise a determining influence on a variety of immune responses in mice, ranging from autoimmunity to their response to tumors ...
BACKGROUND Metastatic melanoma is still one of the most prevalent skin cancers, which upon progression has neither a prognostic marker nor a specific and lasting treatment. Proteomic analysis is a versatile approach with high throughput data and results that can be used for characterizing tissue samples. However, such analysis is hampered by the complexity of the disease, heterogeneity of patie...
BACKGROUND In this work we aimed at sequencing and assembling the goat milk transcriptome corresponding at colostrum and 120 days of lactation. To reconstruct transcripts we used both the genome as reference, and a de novo assembly approach. Additionally, we aimed at identifying the differentially expressed genes (DEGs) between the two lactation stages and at analyzing the expression of genes i...
The MSHl and MSH2 genes of Saccharomyces cerevisiae are predicted to encode proteins that are homologous to the Escherichia coli MutS and Streptococcus pneumoniae HexA proteins and their homologs. Disruption of the MSHl gene caused a petite phenotype which was established rapidly. A functional MSHl gene present on a single-copy centromere plasmid was incapable of rescuing the established mshl p...
•Embryonic hypothalamic microglia are heterogeneous•A subpopulation of embryonic reside adjacent to NSCs•Maternal cold stress impacts signaling nearby NSCs in males•Exposure gestational leads disrupted social behaviors adulthood The interplay between neurons and as they integrate stressors regulate homeostasis is growing interest. We asked if the hypothalamus were likewise responsive and, so, w...
•The brain harbors distinct parenchymal and perivascular macrophages.•Binary split Cre transgenesis allows differential imaging translatome retrieval.•Cx3cr1ccre: Sall1ncre mice specifically target microglia.•Cx3cr1ccre: Lyve1ncre a subset of macrophages. The developmental molecular heterogeneity tissue macrophages is unravelling, as are their diverse contributions to physiology pathophysiology...
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