The analysis of population-speci®c human leukocyte antigen (HLA) has provided evidence that susceptibility to psoriasis is linked to HLA with racial differences (Henseler, 1997). Tumor necrosis factor-a (TNF-a) gene is also mapped within the HLA region and its product has been reported as one of the most important cytokines in the pathogenesis of psoriasis (Uyemura et al, 1993). Recently, HoÈhl...

determining biological equivalence between pioneer and generic products, checking equivalence after change in batch size, detecting changes in components or composition, and checking equivalence after modification of manufacturing equipment or processes. The test method has also been suggested as a possible standard for quality control of topical drug products. We thus established an in vitro d...

1(NAFETIC) Centre, University College of Pharmaceutical Sciences, Kakatiya University, Warangal 506 009, Andhra Pradesh, India. A b s t r a c t Ofloxacin (OFX) is a synthetic broad spectrum analog of second generation fluoroquinolone antibiotic. It is used for the treatment of urinary tract, prostate, skin, urinary and respiratory tract infections. Ornidazole (ORN) is a nitroimidazole derivativ...

In this study, the effects of various hydrophilic (HPMC and Carbopol 971) and plastic (Ethylcellulose and Eudragit RL100) polymers on the release profile of diltiazem HCl from matrix tablets were evaluated in-vitro. For this purpose, tablets containing 60 mg of diltiazem HCl along with various amounts of the aforementioned polymers were prepared using the wet granulation technique. Tablets prep...

In this study, pH sensitive microsphere polymeric drug carriers were produced by using biodegradable natural gelatin and sodium alginate polymers. Microspheres loaded with prepared Ganoderma lucidum extract that is a medicinal mushroom has the potential to be used in several diseases’ treatment. Extract release kinetics of microspheres examined spectrophotometric method an UV spectrometer. Buff...

T. Higuchi, H. Fujii, M. Ikeno, Y. Igarashi, E. Inoue, R. Itoh, H. Kodama, T. Murakami, M. Nakao, K. Nakayoshi, M. Saitoh, S. Shimazaki, S. Y. Suzuki, M. Tanaka, K. Tauchi, M. Yamauchi, Y. Yasu High Energy Accelerator Research Organization (KEK), Tsukuba G. Varner University of Hawaii, Honolulu, Hawaii Y. Nagasaka Hiroshima Institute of Technology, Hiroshima T. Katayama, K. Watanabe Densan Co. ...

Katsuo SETO, Takashi HIGUCHI and Masazumi KAWAKAMI 2nd Department of Physiology, Yokohama City University School of Medicine, Yokohama (Chairman : Professor Masazumi Kawakami) Michiko TAKESHIMA and Makiko KON Biochemical Division, Kanagawa Rehabilitation Center Research Institute, Atsugi Mizuko YAMAJI and Tsuneyuki TSUDA Department of Animal Physiology, Faculty of Agriculture, Tohoku University...

Aim : This study was aimed to formulate a transdermal matrix patch using green tea leaf extract. Materials and methods The formulation optimized by the simplex lattice design method. correlation between responses analyzed chemometrics. observed were: 1. physical properties of patch, 2. percentage dissolution efficiency catechins, caffeine, epigallocatechin gallate released from patch. determina...

The presence of correlated randomness in EEG time series signal buried in random noise was analyzed with the Higuchi fractal algorithm. The signal recognition algorithm design was built on the fact that the theoretical fractal dimension value of 2 is an indicator for a white noise time series and correlated randomness would alter the fractal dimension value from 2. However, the limited number o...

The objective of this study was to develop a sustained release matrix tablet Metoprolol Succinate by cost saving and production efficient process. Among various tablet manufacturing process, direct compression is the simplest and cost saving process. Different trials were formulated and evaluated using different concentrations of directly compressible grade Kollidon SR as release retardant. The...