BACKGROUND There is an urgent need to measure phosphorylated cell signaling proteins in cancer tissue for the individualization of molecular targeted kinase inhibitor therapy. However, phosphoproteins fluctuate rapidly following tissue procurement. Snap-freezing preserves phosphoproteins, but is unavailable in most clinics and compromises diagnostic morphology. Formalin fixation preserves tissu...

A study was conducted to evaluate efficacyof wheat based vs. corn based diets on growth performance, carcass traits,blood parameters, jejunum morphological development, immunity, cecal microflora and excreta moisture in broiler chicks fed according to digestible essential amino acid profile. One hundred forty day old Ross 308 male broiler chicks randomly distributed into ten separated floor pen...

Objective(s):Cyclophosphamide (CP) toxicity on testis was hampered by squid ink polysaccharide (SIP) via restoration of antioxidant ability in our previous investigations. This study investigated roles of Nrf2/ARE signal pathway in testis of treated mice. Materials and Methods: Male Kunming mice were employed to undergo treatment with SIP and/or CP. Protein levels of Nrf2, keap-1, histone deac...

introduction: therapeutic strategies such as chemotherapy can affect gonadal adipose depots. the present study was conducted to assess stereological, morphometric and morphological changes in mouse testicular histoarchitecture structure following bilateral epididymal white adipose tissue lipectomy (biewatx) methods: in this experimental study, adult male mice were divided into three equal group...

background: in radiation therapy, peripheral dose or the dose outside the radiotherapy field, is important when anatomical structures with very low dose tolerances are involved. one of these critical organs in pelvic irradiation is testis. the amount of radiation delivered to the testes in radiotherapy must be kept as small as possible, consistent with the limit dose of this organ. the threshol...

Background Despite the bulk of studies on fatty acid supplementation in maternal diet and confirmed the positive effects on brain and vision, these effects on offspring reproductive organs have not been tested. The aim of the present study was to stereological evaluate the effect of feeding Fish Oil (FO) for mothers on the testis structure of offspring. MaterialsAndMethods Sixty mature female N...

a 2 × 3 factorial experiment was conducted to investigate the effect of enzyme endofeed w (eew) at 0 and 0.05%, thyme essential oil (teo), probiotic primalac® (pp) and non-feed additive, on intestinal histomorphology of broilers fed wheat-based diet. each of the 6 dietary treatments was replicated 4 times with 12 chicks each from 0 to 42 days of age. there was no interaction between enzyme and ...

introduction: cyclophosphamide (cp) is used for the treatment of various cancers. in spite of its therapeutic importance, a wide range of adverse effects such as reproductive toxicity has been observed following the administration of this drug in human and experimental animals. in the current study, we have investigated the adverse effects of cp on morphology and histology of testis rats. metho...

Background: Disruption in spermatogenesis and infertility occurred after local testicular heating. In this study in addition to evaluation the long term effects of experimental bilateral and unilateral cryptorchidism on sperm parameters and structure of mouse testis, the genes that involved in programmed cell death after cryptorchidism and treatment methods of decreasing the germ cells in semin...

background: sodium arsenite and/ or vasectomy may cause variation in sex hormones which affect pathophysiology of reproductive organs. objective: the aim was to investigate the morphological changes in structure of testis and hormonal imbalance in bilateral vasectomised rats treated with sodium arsenite. materials and methods: four groups of rats: bilateral vasectomy + sodium arsenite, bilatera...