BACKGROUND Few studies have been conducted to assess the ambulatory blood pressure (ABP) in IgA nephropathy (IgAN) patients. This study aimed to determine the relationships between ABP and renal histopathological findings assessed using the Oxford classification (OC) and the Japanese classification (JC), which have recently established histopathological criteria for IgAN. METHODS This cross-s...

The study aimed to the investigation of the toxicity of organophosphorus pesticides malathion (MLT) and diazinon (DZN) in Wistar rats in a repeated dose study for 35 days. MLT and DZN in corn oil vehicle were oral administered. Body and organs weights, plasma and brain cholinesterase activities, serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities, histopathologi...

The aim of this study was to investigate effects of subchronic exposure to sublethal levels of diclofenac on growth, oxidative stress, and histopathological changes in Danio rerio. The juvenile growth tests were performed on Danio rerio according to OECD method number 215. Fish at the age of 20 days were exposed to the diclofenac environmental concentration commonly detected in the Czech rivers...

AIM The aim of this study was to determine if nevus-associated melanoma differs in characteristics and prognosis from de novo melanoma. PATIENTS AND METHODS The study included 118 melanoma patients. Clinical findings were retrospectively evaluated. For histopathological parameters, HE sections were reexamined. The differentiation between de novo and nevus-associated melanoma was based on the ...

BACKGROUND A subgroup of meningioma demonstrates clinical aggressive behavior. We set out to determine if the radiological parameters can predict histopathological aggressive meningioma, and propose a classification to predict survival and aggressive meningioma behavior. METHODS A retrospective review of medical records was conducted for patients who underwent surgical resection of their conv...

Previously explored combination therapies mostly involved the use of bioactive molecules. It is believed that herbal compounds containing multiple plant products have synergistic hepatoprotective effects and could enhance the desired actions. To investigate the combination of ethanolic fruits extract of Solanum xanthocarpum (SX) and Juniperus communis (JC) against Paracetamol (PCM) and Azithrom...

The histopathological diagnosis of diffuse astrocytoma is challenging. As the WHO classification system is based on subjective assessments, the prognosis for the individual patient is somewhat uncertain. The aim of this study was therefore to investigate the prognostic value of various histological features, Ki-67/MIB-1 labeling index (LI), and clinical factors. The study was designed as a retr...

Exposure of the body organs and systems to pesticides including lindane has found been to cause adverse effects, which affect functionality. Hence, this study was aimed at determining the ability, potency and nature of Moringa oleifera leaf in the protecting testis against lindane induced testicular damage based on some biochemical and histopathological parameters. Adult male rats were orally a...

AIM Contrast-induced nephropathy (CIN) is a common cause of hospital-acquired acute renal failure. Although it is so common, there has been no approved therapy yet. We aimed to investigate the effect of grape seed proanthocyanidin extract (GSPE) on preventing CIN. MATERIALS AND METHODS 24 rats were divided into four groups as control group, GSPE group, contrast medium (CM) group, and CM+GSPE ...

The aqueous and ethanol extracts of the leaves of Basella alba L. var. alba Wight, Basellaceae, were investigated for antiulcer activity on rats employing the pylorus ligation and ethanol induced ulcer models. The various gastric secretion parameters such as total acidity, free acidity, gastric acid volume, pH and histopathological parameters such as ulcer index and percent protection were comp...