نتایج جستجو برای: hmc
تعداد نتایج: 1106 فیلتر نتایج به سال:
Tet proteins oxidize 5-methylcytosine (mC) to generate 5-hydroxymethyl (hmC), 5-formyl (fC), and 5-carboxylcytosine (caC). The exact function of these oxidative cytosine bases remains elusive. We applied quantitative mass-spectrometry-based proteomics to identify readers for mC and hmC in mouse embryonic stem cells (mESC), neuronal progenitor cells (NPC), and adult mouse brain tissue. Readers f...
We present a method for fast optimal estimation of the temperature angular power spectrum from observations of the cosmic microwave background. We employ a Hamiltonian Monte Carlo (HMC) sampler to obtain samples from the posterior probability distribution of all the power spectrum coefficients given a set of observations. We compare the properties of the HMC and the related Gibbs sampling appro...
The absolute levels of 5-hydroxymethylcytosine (hmC) and 5-methylcytosine (mC) in human brain tissues at various ages were determined. Additionally, absolute levels of 5-formylcytosine (fC) in adult individuals and cytosine modification levels in sorted neurons were quantified. These data were compared with age-related fC, hmC, and mC levels in mouse brain samples. For hmC, an initial steady in...
In this commentary, I call for maintaining the archipelagic character of human-machine communication (HMC). Utilizing metaphor archipelago or a chain connected islands indicates that HMC entails variety differing in shape, size, location, and proximity to one another. Rather than aiming conceptual unity definitional homogeneity, embracing cultivated ambiguity related key concepts. Ambiguity sen...
Hemocyanin (HMC) has been shown to participate in multiple roles of immune defence. In this study, we investigated the antiproliferative effect and underpinning mechanism of HMC from Litopenaeus vannamei in vitro. Sulforhodamine B (SRB) assay indicated that HMC could dramatically inhibit the growth of HeLa cells, but not 293T cells under the same conditions. Moreover, typical morphological feat...
We describe a new Hybrid Monte Carlo (HMC) algorithm for dynamical overlap fermions, which improves the rate of topological index changes by adding an additional (intensive) term to the action for the molecular dynamics part of the algorithm. The metropolis step still uses the exact action, so that the Monte Carlo algorithm still generates the correct ensemble. By tuning this new term, we hope ...
A higher tier of network packet processing performance can be achieved by augmenting the agility that FPGAs offer with the sheer streaming throughput offered by a Hybrid Memory Cube (HMC). The notion of a programmable data plane specified in a domain-specific language enables the creation of custom protocol and packet operations. This paper presents an effort to map one such domain specific lan...
The mechanism responsible for developmental stage-specific regulation of γ-globin gene expression involves DNA methylation. Previous results have shown that the γ-globin promoter is nearly fully demethylated during fetal liver erythroid differentiation and partially demethylated during adult bone marrow erythroid differentiation. The hypothesis that 5-hydroxymethylcytosine (5 hmC), a known inte...
The goal of this study was to examine three interfaces for handheld mobile computing (HMC) on the iPhone and then assess against a standard personal computer (PC) interface. While designers originally envisioned similar performance between HMC and PC, our results indicate differences between these platforms. However, specialized mobile sites and applications (Apps) greatly enhanced HMC performa...
Systemic lupus erythematosus (SLE) is a chronic, potentially fatal systemic autoimmune disease characterized by the production of autoantibodies against a wide range of self-antigens. To investigate the role of the 5-hmC DNA modification with regard to the onset of SLE, we compared the levels 5-hmC between SLE patients and normal controls. Whole blood was obtained from patients, and genomic DNA...
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