MOTIVATION Hot spots are residues comprising only a small fraction of interfaces yet accounting for the majority of the binding energy. These residues are critical in understanding the principles of protein interactions. Experimental studies like alanine scanning mutagenesis require significant effort; therefore, there is a need for computational methods to predict hot spots in protein interfac...

background and aims: one of the most common approach to understanding spatial and temporal trends of event data is to break it up into a series of time snapshots. therefore space-time cube method applied in order to portray the likely trend in occurrence of the pulmonary tuberculosis (tb) cases. methods: in this study, information of all patients with pulmonary tb recorded in surveillance syste...

Highly prized is the truly productive crime prevention strategy, one that lightens the load on an overworked criminal justice system and, more importantly, reduces the number of victims. But to prevent crimes—especially in hot spots (high-crime areas)—police must determine where and when crimes are likely to occur. Drawing primarily on data collected in the United Kingdom, this Research in Acti...

Fumaroles (steam vents) are the most common, yet least understood, microbial habitat in terrestrial geothermal settings. Long believed too extreme for life, recent advances in sample collection and DNA extraction methods have found that fumarole deposits and subsurface waters harbor a considerable diversity of viable microbes. In this study, we applied culture-independent molecular methods to e...

Several analytical models of fully-adaptive routing have recently been proposed for wormhole-routed k-ary ncubes under the uniform traffic pattern. However, there has been hardly any model reported yet that deals with other important non-uniform traffic patterns, such as hot spots. As a result, most studies have resorted to simulation when evaluating the performance merits of adaptive routing. ...

We calculate the first vertex correction δΛ k to the bare vertex Λ • in the nearly antiferromagnetic spin fluctuation Fermi liquid theory of the cuprate superconductor YBa 2 Cu 3 O 7. It is calculated for k on the Fermi surface, and Q = (± π a , ± π a). We find that the dimensionless ratio |δΛ k |/Λ • , which parametrizes the vertex correction, is not small. It is a maximum for k = k h , where ...

Telecommunication switches implement overload controls to maintain call throughput and delay at acceptable levels during periods of high load. Existing work has mostly focused on controls under sustained overload–they do not meet the demands of modern telecommunication systems where the increased number of services and mobile subscribers often creates fast changing hot spots. We introduce new a...