نتایج جستجو برای: hoxa
تعداد نتایج: 509 فیلتر نتایج به سال:
a massive sequencing approach of a cDNA library, the whole set of Hox genes of the chondrichthyan, Scyliorhinus canicula. We have sequenced seven BAC clones that include all of the HoxA, HoxB and HoxD clusters. The transcriptomic data suggests that no HoxC genes have been maintained in this species. The expression of the posterior Hox genes was studied by insitu hybridization and showed that al...
a massive sequencing approach of a cDNA library, the whole set of Hox genes of the chondrichthyan, Scyliorhinus canicula. We have sequenced seven BAC clones that include all of the HoxA, HoxB and HoxD clusters. The transcriptomic data suggests that no HoxC genes have been maintained in this species. The expression of the posterior Hox genes was studied by insitu hybridization and showed that al...
a massive sequencing approach of a cDNA library, the whole set of Hox genes of the chondrichthyan, Scyliorhinus canicula. We have sequenced seven BAC clones that include all of the HoxA, HoxB and HoxD clusters. The transcriptomic data suggests that no HoxC genes have been maintained in this species. The expression of the posterior Hox genes was studied by insitu hybridization and showed that al...
INTRODUCTION Alzheimer's disease is a neurodegenerative disorder that is hypothesized to involve epigenetic dysregulation of gene expression in the brain. METHODS We performed an epigenome-wide association study to identify differential DNA methylation associated with neuropathology in prefrontal cortex and superior temporal gyrus samples from 147 individuals, replicating our findings in two ...
As the most common cause of cancer death in women, the pathogenesis of breast cancer still remains unclear. Here, we reported a long non-coding RNA (lncRNA), HOTTIP (HOXA transcript at the distal tip), that may play an important role in the pathogenesis of breast cancer. Using gain-and-loss-of experiments in vitro and in vivo, we observed the marked upregulation of HOTTIP/HOXA11 in the breast c...
Homeotic genes code for key transcription factors (HOX-TFs) that pattern the animal body plan. During embryonic development, Hox genes are expressed in overlapping patterns and function in a partially redundant manner. In vitro biochemical screens probing the HOX-TF sequence specificity revealed largely overlapping sequence preferences, indicating that co-factors might modulate the biological f...
زمینه و هدف: ملانوما یکی از انواع سرطان پوست است که نسبت به سایر سرطان های پوست خطرناک تر می باشد. یکی از عوامل موثر در ایجاد سرطان ها، گروهی از RNA های غیر کد کننده اند که به نام lncRNA (long noncoding RNA) شناخته می شوند. این مولکول های غیر کد کننده بیش از 200 باز طول دارند و به عنوان یک تنظیم کننده در پیشرفت سرطان عمل می کنند Hottip (HOXA transcript at the distal tip) یک lncRNA ی بین ژنی است...
Homeoprotein products of the Hox/HOM gene family pattern the animal embryo through the transcriptional regulation of target genes. We have previously shown that the labial group protein HOXA-1 has intrinsically weak DNA-binding activity due to residues in the N-terminal arm of its homeodomain (M. L. Phelan, R. Sadoul, and M. S. Featherstone, Mol. Cell. Biol. 14:5066-5075, 1994). This observatio...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید