transforming growth factor betas are multifunctional polypeptides in the cytokine superfamily. they have a growth inhibitory role on hemopoietic progenitor cells in semisolid colony assay as well as in long-term bone-marrow culture. tgf - β2 represses stromal cells, stem cell factor gene transcription, and decreases the stability of c-kit transcripts in hemopoietic cells. tgf-β also modulates g...