An approximately 1-year-old domestic rabbit showed severe neurologic signs with circling and turning somersaults. Histologically, a nonsuppurative meningoencephalitis with neuronal cell necrosis and numerous intranuclear inclusion bodies in neurons and glial cells was found. Electron microscopic examination revealed herpesvirus particles in affected cells. A human herpes simplex virus was ident...

A strain of Amycolatopsis orientalis No. Q427-8 (ATCC 53884) was found to produce a complex of new antiviral antibiotics, quartromicin which consisted of at least six components A1, A2, A3, D1, D2 and D3. Structural studies suggested that they are a novel type of molecules unrelated to any known antibiotics. Each component of quartromicin exhibited antiviral activity against herpes simplex viru...

The characteristic site-specific reactivation phenotypes of HSV-1 and HSV-2 depend upon the latency-associated transcript region. Increasing proportion of herpes simplex virus type 1 as a cause of genital herpes infection in college students. episodes of genital herpes in a Swedish STD population: a study of epidemiology and transmission by the use of herpes simplex virus (HSV) typing and speci...

In this report, a 32 year-old patient is reported who was suffering from recurrent genital herpes for 3 years and her disease could not be controlled with conventional treatment methods. But, application of Imiquimod 5% cream, 3 times a week for 3 months, proved very effective with no recurrence for up to 7 months. Since recurrent genital herpes is the result of some immunologic dysfunctions ca...

OBJECTIVES Demonstrate that DNA viremia is common in pediatric sepsis and quantitate its associations with host immune function and secondary infection risk. DESIGN Retrospective analysis of a prospective cohort study. PATIENTS Seventy-three children admitted with sepsis-induced organ failure. INTERVENTIONS None. MEASUREMENTS AND MAIN RESULTS This study was performed as an ancillary inv...

herpes simplex esophagitis (hse) has rarely been reported in immunocom­petent individuals. in a search of medline until october 2012, we found only one case of hse in a pregnant female. we present the first case of hse in a healthy 36-year-old female at 27 weeks gestation who recovered without an­tiviral therapy. normal 0 false false false en-us x-none fa

OBJECTIVE To determine the prevalence of herpes viruses in the semen of an asymptomatic male cohort with and without infertility problems and its association with altered semen parameters. DESIGN A prospective randomized study. SETTING Medical school and IVF clinic. PATIENT(S) One hundred seventy-two male patients undergoing routine semen analysis: 80 with normal semen parameters (control...

Human herpes virus 8 (HHV-8) or Kaposi sarcoma-associated herpes virus is the etiologic agent of Kaposi sarcoma, primary effusion lymphoma, and plasma cell-type multicentric Castleman disease (MCD). HHV-8 encodes a viral homolog of human IL-6, called viral IL-6 (vIL-6), which does not require the cellular IL-6 receptor for binding to the ubiquitously expressed gp130 receptor subunit and subsequ...

Tumor necrosis factor-alpha (TNF-α) inhibitors are immunosuppressive agents used in a variety of inflammatory diseases, including rheumatoid arthritis (RA), spondyloarthritis, psoriasis, and bowel disease (IBD). Kaposi’s sarcoma (KS) is an angioproliferative associated with the human herpes virus 8 (HHV-8). We present 46-year-old male patient ankylosing spondylitis (AS) treated TNF-α inhibitor ...