Abstract Background iPSC (induced pluripotent stem cells) banks of lines with homozygous HLA (human leukocyte antigen) haplotypes (haplobanks) are proposed as an affordable and off-the-shelf approach to allogeneic transplantation derived cell therapies. Cord blood offer extensive source HLA-typed cells suitable for reprogramming iPSC. Several initiatives worldwide have been undertaken create na...

The regulation of immune mechanisms is controlled by major histocompatibility complex/human leukocyte antigen (MHC/HLA). Polymorphisms the HLA region have an impact on susceptibility to complex infectious and autoimmune diseases. present study was carried out determine frequencies ASMA, AMA, ANA, dsDNA, anti-LKM-1 auto-antibodies in hepatitis C patients their association with DRβ1 (*04) locus. ...

Abstract Background Coronavirus disease 2019 (COVID-19) continues to be a major public health challenge globally. The identification of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-derived T-cell epitopes is critical importance for peptide vaccines or diagnostic tools COVID-19. Methods In this study, several SARS-CoV-2-derived human leukocyte antigen (HLA)-I binding peptides wer...

Background: The Human Leukocyte Antigen (HLA) is the most polymorphic region in human genome. Moreover, HLA haplotype frequencies are largely used in transplantation, the treatment of autoimmune diseases, and population-based studies. The present study aimed to determine HLA-A, -B, -DR alleles and haplotype frequencies in 88 unrelated donors of Iranian Gilak ethnic group, by Polymerase Chain Re...

PURPOSE Human leukocyte antigen-G (HLA-G) is a tumor-associated immunosuppressive molecule involved in tumor escape mechanisms. The aim of this study is to elucidate its prognostic significance in hepatocellular carcinoma (HCC). EXPERIMENTAL DESIGN Immunohistochemical staining of HLA-G expression as well as tumor-infiltrating FoxP3+ regulatory (Tregs) and CD8+ cytotoxic T cells was carried ou...

common variable immunodeficiency (cvid) is a heterogeneous heritable disease characterized by arrest in b cell differentiation. an association between cvid and two hla haplotypes, haplotype i (hla-a1, hla-b8, hla-dr3) and haplotype ii (hla-a29, hla-b44, hladr7)has been previously documented. in the present study, we have attempted to find an association between susceptibility to cvid and hla cl...

Hypersensitivity to beryllium (Be) is found in 1-16% of exposed workers undergoing immunological screening for beryllium disease using the beryllium lymphocyte proliferation test (BeLPT). However, only approximately 50% of BeLPT-positive workers present with lung granulomas (i.e. berylliosis). As berylliosis is associated with the human leukocyte antigen (HLA)-DP supratypic marker DPGlu69, the ...