Using optimal culture conditions in which the transforming growth factor beta 1 (TGF-beta 1) inhibitory loop has been interrupted by antisense TGF-beta 1 oligonucleotides or anti-TGF-beta serum, we have compared the proliferative capacities and the abilities of the CD34+ CD38- cell populations from bone marrow and umbilical cord blood to generate early progenitors in long-term cultures. The CD3...

Background: In recent decade, human umbilical cord blood derived mesenchymal stem cells (hUCB-MSCs) provide enormous potential for appropriate cell therapy, but they have limited growth potential and cease to proliferate due to cellular senescence, so providing a strategy for increasing the stem cell survival is necessary.  Methods: In this investigation, MSCs characterized by flow cytome...

There is currently no consensus among clinicians and scientists over the appropriate or optimal timing for umbilical cord clamping. However, many clinical studies have suggested that delayed cord clamping is associated with various neonatal benefits including increased blood volume, reduced need for blood transfusion, increased cerebral oxygenation in pre-term infants, and decreased frequency o...

Umbilical cord blood (UCB) stem cells [4] are hematopoietic stem cells [5] (HSC) that are recovered from the blood of the umbilical cord [6] and placenta [7] after birth. Umbilical cord blood is rich in cells that express the CD34 molecule, a surface protein that identifies cells as stem cells [4]. Prior to the discovery of UCB stem cells [4], it was standard procedure to discard the umbilical ...

BACKGROUND There are no definitive markers to aid in diagnosis of neonatal encephalopathy (NE). The purpose of our study was (1) to identify and evaluate the utility of neuronal nitric oxide synthase (NOS1) in umbilical cord blood as a NE biomarker and (2) to identify the source of NOS1 in umbilical cord blood. METHODS This was a nested case-control study of neonates >35 weeks of gestation. E...

total serum copper levels of 70 pregnant women hospitalized for delivery at misaghieh (private), 90 at farah (public) maternity hospitals immediately after delivery and 27 non-pregnant women (control) were measured. the copper level in the blood serum of umbilical cord of the newborn infants was also determined. the copper levels were significantly elevated in both pregnant groups as compared t...

conclusion reference ranges for umbilical cord csa have been generated. the csa of the umbilical cord and other components of it increase as a function of gestational age. these measurements correlate with fetal size. results the values of the csa of the umbilical cord, umbilical vein and wharton’s jelly (wj) increase consistently until 30 weeks of gestation, after which they reach a plateau. t...

Umbilical cord blood stem cell transplants are used to treat a variety of oncologic, genetic, hematologic, and immunodeficiency disorders. Physicians have an important role in educating, counseling, and offering umbilical cord blood donation and storage options to patients. Parents may donate their infant's cord blood to a public bank, pay to store it in a private bank, or have it discarded. Th...

Objective: In this study, we aimed to investigate umbilical cord blood CD33 and erythropoietin (EPO) levels of pregnants with abnormal umbilical and uterine artery doppler waveforms and to compare with normal pregnancies. Materials and Methods: Total 40 pregnant women were included in this study. Of these 40 women, while 20 patients had abnormal umbilical and uterine artery doppler waveforms, t...