Abstract Hypersensitivity reactions to corticosteroids, either immediate or delayed, represent a clinical paradox as one would not expect such compounds with anti-inflammatory and immunomodulatory effects. We present the case of 67-year-old patient referred our service three episodes delayed hypersensitivity reaction steroids. The first episode occurred in 2016 when was treated for chest infect...

Tumors were induced in mice with 20-methylcholanthrene for the purpose of studying the anti-cancer activity of steroids. Repeated subcutaneous injections of 20-methylcholanthrene (MC) were used to induce sarcomas in two strains of mice, BALB/c males and CSH/Jax females. Over 80 per cent of the BALB/c and 100 per cent of the C3H mice developed tumors within 90 days after the start of carcinogen ...

QuEChERS sample preparation was optimized using solvent extraction with acetonitrile and dispersive-solid phase extraction with primary and secondary amine sorbents, and validated for high-performance liquid chromatographic determination of nine steroids commonly used to adulterate herbal medicines: such as triamcinolone, prednisolone, hydrocortisone, methylprednisolone, betamethasone, dexameth...

Infection of human foreskin cells (D-550) by the Snyder-Theilen strain of feline sarcoma virus produced small but countable foci and demonstrated "single-hit" dose-response kinetics. Significant quantitative and qualitative enhancement of focus formation was observed when the glucocorticoid hormones, dexamethasone, hydrocortisone, cortisol acetate, and prednisolone were added to cell cultures (...

There can be no doubt that cortisone and its analogues have revolutionized the treatment, and to a lesser extent the diagnosis, of endocrine diseases during the last decade. Although available through the pharmaceutical houses in a wide variety of different formulations to meet particular needs, these steroids can be classified into three main groups according to their influence on salt and wat...

EXPERIENCE of the limitations of cortisone and hydrocortisone as therapeutic agents in the management of patients with rheumatoid arthritis has led to a search for newer and more potent compounds with fewer undesirable side effects. With the knowledge that the physiological properties of the adrenal steroids can be modified by relatively minor adjustments of their structural formula, a number o...

Dermatitis caused by bombardier beetles is rarely reported. Here, we report a case of beetle-caused dermatitis that occurred in Pará State, the Brazilian Amazon. A female patient while putting on her shoes, felt a burning pain in the right hallux and noticed a beetle inside the shoe. During medical consultation, the physician observed that the injury site was brown and discolored. The patient c...

this study aimed to compare the efficacy of dexamethasone and hydrocortisone in the treatment of acute paediatric asthma. forty seven asthmatic children were randomised to receive either dexamethasone (0.6 mg/ml, maximum 16 mg) in a single dose or hydrocortisone (8-10 mg/kg/day) in 4 equal doses for 2 days. our findings showed that the mean length of hospitalization in children receiving dexame...

The effects of intra-articular methotrexate (MTX) were compared with saline in 20 patients with persistent knee effusions due to rheumatoid arthritis (15) and psoriasis (5) in a double-blind pilot study. Clinical improvement was seen in most patients given either MTX or saline and was attributed to joint irrigation during arthroscopy and the placebo effects. MTX had a local anti-inflammatory ef...

In 1953 it was demonstrated by EngelbrethHolm and Asboe-Hansen (3) that intraperitoneal injection of cortisone markedly inhibits the devel opment of skin tumors and prolongs the latent period in ST/Eh mice painted once on the dorsum with 9,10-dimethyl-l,2-benzanthracene. In further experiments by Zachariae and AsboeHansen (4), hydrocortisone (17-hydroxycorticosterone) acetate, injected topicall...