Heterogeneous catalysis plays a key role in the manufacture of essential products in key areas of agriculture and pharmaceuticals, but also in the production of polymers and numerous essential materials. Our understanding of heterogeneous catalysts is advancing rapidly, especially by using the latest characterisation methods on these relatively complex effect materials. At the heart of these ca...

BYZX, [(E)-2-(4-((diethylamino)methyl)benzylidene)-5,6-dimethoxy-2,3-dihydroinden-one], belongs to a series of novel acetylcholinesterase inhibitors and has been synthesized as a new chemical entity for the treatment of Alzheimer's disease symptoms. When incubated with human liver microsomes (HLMs), BYZX was rapidly transformed into its metabolites M1, M2, and M3. The chemical structures of the...

biological structures and functions. It is suitable for the analysis of biological interactions because it is based on the affinity of the ligand moiety. Various photophors, such as phenyldiazirine, arylazide and benzophenone, were used. Comparative irradiation studies of these three photophors in living cells suggested that a carbene precursor, (3-trifluoromethyl) phenyldiazirine, is the most ...

Amorphous silicon (a Si) is common in the production of technical devices and can be deposited by several techniques. In this study intrinsic and doped, hydrogen less amorphous silicon films are RF magnetron sputter deposited and post hydrogenated in a remote hydrogen plasma reactor at a temperature of 370 °C. Secondary ion mass spectrometry of a boron doped (p) a Si layer shows that the concen...

Tandem reactions and consecutive catalysis (or relay catalysis) have been receiving considerable attention in organic synthesis due to their abilities of constructing multiple new chemical bonds to build complex chiral molecules in a single operation. Transition-metal-catalyzed asymmetric hydrogenation is one of the most widely used and reliable catalytic methods for preparation of chiral molec...

New chiral ferrocenyldiphosphine ligands (R)-(S)-3 and (R)-(S)-4 were prepared. The ligands were employed in Ru(II) catalyzed asymmetric transfer hydrogenation of ketones to give corresponding secondary alcohols. Up to 99% conversion with 90% e.e. was obtained on Ru(DMSO)4Cl2/4 in transfer hydrogenation of acetophenones with propan-2-ol. © 2003 Elsevier B.V. All rights reserved.

A series of acid-labile, optically pure ε-substituted δ-ketal-β-hydroxy esters were obtained by a Ru-SunPhos catalyzed asymmetric hydrogenation of the corresponding ε-substituted δ-ketal-β-keto esters. CaCO(3) played a dual role in the hydrogenation reaction--removing the acid generated during the formation of the catalyst and maintaining the activity of the catalyst.

Various aldoximes and ketoximes were selectively reduced to the corresponding amines by catalytic transfer hydrogenation employing low cost magnesium powder and ammonium formate at room temperature. Many other functionalities such as halogens, –OH, –OCH3, –COOH and –CH3 remained unaffected. The hydrogenation is fast, mild, clean, cost effective and high yielding.

A microreactor of hollow polymeric microspheres with Pd nanoparticles immobilized in its wall is designed for hydrogenation of olefins under organic/aqueous biphasic catalysis. The microreactor has an ability to encapsulate and concentrate olefins within the vacancy of the hollow microspheres in the aqueous phase, and therefore hydrogenation within the microreactors runs efficiently with concen...

Ir complexes of chiral phosphine-diamine ligands catalyse the hydrogenation and transfer hydrogenation of aryl-piperidin-4-yl methanones, and ketones bearing both an aryl group and secondary alkyl substituent with up to 98% e.e., and with substrate to catalyst ratios of up to 4000.