The pathogenesis of scleroderma (SSc) includes components of autoimmunity, vascular dysfunction, and accumulation of extracellular matrix. 8-isoprostane, an oxidized lipid created by oxidative stress, activates the thromboxane A2 receptor (TXAR) and the Rho-associated kinase (ROCK) pathway. In this study, we determined whether the TXAR was activated by 8-isoprostane in SSc endothelial cells (EC...

Disorders of angiogenesis are related to microangiopathies during the development of diabetic vascular complications, but the effect of advanced glycation end products (AGEs) on angiogenesis and the mechanism has not been completely unveiled. We previous demonstrated that moesin belonging to the ezrin-radixin-moesin (ERM) protein family protein played a critical role in AGE-induced hyper-permea...

Objectives: It is important to recognize any risk factors for the development of injuries in the athletic population. The aim of this study was to investigate the association between joint hyper mobility and low back pain in Iranian hyper mobile and non-hyper mobile athletes. Methods: 50 athletic patients with low back pain (age=23.20±12.79 years) and 51 healthy athletes (age=24.28&pl...

We consider the notion of an isomorphism between two hyper BCI-algebras and obtain all of the hyper BCI-algebras of order 3. It is shown that there exist 14 proper hyper BCI-algebras and 5 proper weak hyper BCI-algebras of order 3 up to isomorphism. Finally, further study on the theory of hyper BCI-algebra and its related hyper structure and applications of our results in information sciences a...

The notions of bipolar fuzzy hyper MV-subalgebras, (weak) bipolar fuzzy hyper MV-deductive system and precisely weak bipolar fuzzy hyper MV-deductive system are introduced, and their relations are investigated. Characterizations of bipolar fuzzy hyper MV-subalgebras and weak bipolar fuzzy hyper MV-deductive systems are provided.

hyper - immunoglobulin e syndrome is a rare primary immunodeficiency disease characterized by recurrent abscess formation, respiratory tract infections and very high titers of serum ige associated with peculiar face and skeletal features. we report a seven-year old  girl  presenting with persistent productive cough and  history of chronic eczematoid facial lesions since infancy  and  two episod...

There is a growing interest towards self configuring/tuning automated general-purpose reusable heuristic approaches for combinatorial optimisation, such as, hyper-heuristics. Hyper-heuristics are search methodologies which explore the space of heuristics rather than the solutions to solve a broad range of hard computational problems without requiring any expert intervention. There are two commo...

Fuzzy (weak) implicative hyper K-ideals are introduced, and relations among fuzzy weak implicative hyper K-ideals, fuzzy implicative hyper K-ideals and fuzzy hyper K-ideals are discussed.

Based on Maxwellian quaternionic electromagnetic theory, the octonionic hyper-strong field, hyper-weak field and the quantum interplays can be presented by analogy with octonionic electromagnetic, gravitational, strong and weak interactions. In the hyper-weak field, the study deduces some conclusions of field source particles and intermediate particles which are consistent with Dirac equation, ...