Vitamin D deficiency is associated with several alterations in mineral metabolism [1]. Initially, the development of secondary hyperparathyroidism maintains normal circulating 1,25-dihydroxyvitamin D (1,25-vitamin D) and serum calcium values, but both these values decrease in advanced vitamin D deficiency. Serum phosphorus values usually decrease because of secondary hyperparathyroidism, but ra...

BACKGROUND AND OBJECTIVES Several factors might alter serum phosphate homeostasis and induce hyperhosphatemia in patients with chronic kidney disease (CKD) not requiring dialysis. However, whether and to what extent hyperphosphatemia is associated with a poor prognosis in different CKD patient groups remain to be elucidated. DESIGN, SETTING, PARTICIPANTS & MEASUREMENTS We utilized the "Preven...

Hb F, some of which is glycated (2), accounts for the majority (70%–95%) of Hb species in newborns. About 5%– 30% is Hb A, with none to trace amounts of Hb A1c. This patient’s sample was collected after transfusion of 2 aliquots of red blood cells from a single donor. The donor’s blood contained 12.6% Hb A1c. Concentrated glucose in blood storage media increases donor Hb A1c only minimally (3, ...

Nutritional problems in hemodialysis (HD) patients are frequently associated with poor control of serum phosphorus what may lead to chronic kidney disease-metabolic bone disease. Hyperphosphatemia is an important risk factor for extraskeletal and vascular calcifications and is associated with cardiovascular morbidity and mortality. Increased ingestion of phosphorus is an important factor in dev...

Hypoparathyroidism-Retardation-Dysmorphism (HRD) syndrome, also known as Sanjad Sakati Syndrome (SSS), is a rare autosomal recessive genetic condition seen in offspring of consanguineous parents of Middle Eastern origin. HRD consists of hypoparathyroidism leading to hypocalcemia and hyperphosphatemia, growth retardation, and characteristic dysmorphic features. This case presents a Saudi baby gi...

Over the last 15 years, our knowledge and understanding of the underlying mechanisms involved in the regulation of calcium and phosphate homeostasis in chronic kidney disease have advanced dramatically. Contrary to general opinion in the 20(th) century that moderate hypercalcemia and hyperphosphatemia were acceptable in treating secondary hyperparathyroidism, the calcium and phosphate load is i...