A 52-year-old woman with nonspecific left leg pain was examined by Tc-99m methylene diphosphonate (MDP) bone scintigraphy. The patient had been a marble quarry worker for 10 years and had developed chronic congestive heart failure secondary to pneumoconiosis. Her hemoglobin analysis and hematologic findings were interpreted as being consistent with sickle cell beta+ thalassemia and also hypersp...

A method is proposed to reduce portal hypertension utilizing subtotal splenectomy and a central splenorenal shunt. The advantages of this method are: diversion of the splenic component of the portal circulation, creation of a shunt for the portal blood into the systemic circulation, preservation of the splenic function and correction of the manifestations of the hypersplenism. Two cases are pre...

Introduction: Bone marrow aspiration (BMA) is an important tool in diagnosis of many haematological and non-haematological diseases. BMA usually done together with complete blood cell count (CBC) peripheral picture. needed for hypersplinsm. alone sufficient megaloblastic anaemia, microcytic acute leukaemia, chronic myeloid lymphocytic leukaemia immune thrombocytopenic purpura (ITP). The objecti...

A patient with progressive multifocal leucoencephalopathy was found to have primary hypersplenism, a benign disorder of the reticuloendothelial system. He failed to respond to conventional doses of corticosteroids. The clinical and pathological manifestations of his illness are described, and the development of the histopathological changes in the nervous system is discussed. Consideration of a...

A 54-year-old Chinese woman with a history of alcoholic cirrhosis and hypersplenism presented in 2003 with bilateral peri-orbital, malar, and glabellar swelling (Fig 1). She had a history of milder glabellar swelling 7 years ago. An incisional biopsy of the lesion taken at that time showed granulomatous inflammation. She subsequently failed to attend for follow-up. She came back when she discov...

Five patients in the blastic phase of chronic granulocytic leukemia with massive splenomegaly were treated by intraarterial splenic artery infusion of cytosine arabinoside. All patients had massive splenomegaly associated with pain and/or hypersplenism and were refractory to previous therapy. All 5 patients demonstrated responses to treatment, with reduction in spleen size as well as symptomati...

Objective: To determine the frequency of underlying causes of pyrexia of unknown origin on bone marrow examination. Study Design: Descriptive study. Place and Duration of Study: The study was carried out at Hematology department (pathology) of Army Medical College, National University of Sciences and Technology (NUST) and Military Hospital Rawalpindi (during the period of one year) from Jan 201...

The purpose of this study was to evaluate the efficacy and toxicity of recombinant human granulocyte colony-stimulating factor (rhG-CSF) therapy in patients with neutropenia and/or neutrophil dysfunction secondary to glycogen storage disease (GSD) type 1b. Thirteen patients with neutropenia and/or neutrophil dysfunction secondary to GSD type 1b were treated with rhG-CSF. The effects of therapy ...