h E safety of vitamin-D supplementation has been the subject of editorials and statements by pediatric associations, both in Great Britain 1-1 and in the United States 8-11 for more than 12 years, ever since infantile hypercalcemia was correlated with hypervitaminosis D. •• Frank overdose with vitamin D, and hyperreactivity to amounts of vitamin D far lower than those usu· ally deemed toxic, ha...

Introduction Vit D level is low in human milk (20-60 IU/Lit) thus dialy supplement of 400 Vit D is advised since birth for all infants. On the other hand upper limit dose for long term Vit D intake is 1000 IU/day for children less than one year of age. Excessive Vit D more than upper limit by physicians or parents can cause hypervitaminoseD. We report a rare case of hypervitaminose D in two mon...

introduction vit d level is low in human milk (20-60 iu/lit) thus dialy supplement of 400 vit d is advised since birth for all infants. on the other hand upper limit dose for long term vit d intake is 1000 iu/day for children less than one year of age. excessive vit d more than upper limit by physicians or parents can cause hypervitaminosed. we report a rare case of hypervitaminose d in two mon...

The objective of the study is to evaluate alterations of bone metabolism in adolescence and adult CF, determining the rate of osteoporosis, osteopenia and vertebral and non-vertebral fractures. We took into account the clinical case of a child who right from the age of seven years has presented joint pain.The little girl was diagnosed with osteopenia taken with therapy of calcium and vitamin D;...

The purpose of this review is to examine vitamin D in the context of sport nutrition and its potential role in optimizing athletic performance. Vitamin D receptors (VDR) and vitamin D response elements (VDREs) are located in almost every tissue within the human body including skeletal muscle. The hormonally-active form of vitamin D, 1,25-dihydroxyvitamin D, has been shown to play critical roles...

OBJECTIVE Vitamin D is a fat-soluble secosteroid hormone that regulates calcium, magnesium, and phosphate homeostasis and plays a pivotal role as antiproliferative and immunomodulatory mediator. Considering the different sources of synthesis and dietary intake as well as the pleiotropic actions in extremely diverse (micro)environments of the body, the supplementation of this Vitamin should be c...

BONE lesions have been described in animals given large doses of vitamin A. The bones are reduced in thickness and fractures are frequent (Moore, 1957). Much of this work has been done on the rat (Moore and Wang, 1945; Wolbach, 1947; Thompson and Pitt, 1960), but lesions have been described in other species including guinea-pigs (Wolbach, 1947), calves (Grey, Nielsen, Rousseau, Calhoun and Eato...

A high incidence of band keratopathy was observed in a rabbit colony being utilized in uveitis experiments. Unrelated to the uveitis, the animals had developed, in addition to the corneal lesions, deposits of calcium in the kidneys, arterial tree, trachea, and smooth muscle of the intestine suggestive of hypercalcemia due to an accidental hypervitaminosis D. The clinical and histopathologic cha...

1. Serum levels of retinol-binding protein (RBP), total vitamin A and retinyl ester were measured in twenty-four malnourished children with corneal lesions and nine normal children. 2. Initially, the RBP and vitamin A levels were significantly lower in malnourished children than in normal children. 3. After intramuscular injection of 30000 microgram of aqueous vitamin A, serum levels of total v...