The present study was performed to investigate the effect of ritonavir on the pharmacodynamics of gliclazide in rats (normal and diabetic) and rabbits to evaluate the safety and effectiveness of the combination. All blood samples were analyzed for blood glucose by the GOD/POD method and insulin in rabbit blood samples by the radioimmunoassay method. Ritonavir alone produced significant elevatio...

  Background: Hypoglycemic effect of Juglans regia leaves was reported in other previous researches.   Objective: To investigate the mechanism of hypoglycemic action of Julans regia Leaves Methanolic Extract (JRLME), we designed the following study.   Methods: Male wistar rats were classified in five groups, each of six, including alloxan-induced diabetic rats treated with JRLME at doses of 250...

By a series of structural changes, Frank, Nothmann, and Wagner (1) developed synthalin, the most powerful hypoglycemic synthetic product known today. The details of their researches are not available. The increased hypoglycemic activity of agmatine over guanidine offered the first clue as to the nature of the groups which were productive of hypoglycemic activity. It may be gathered from the rec...

The present study was carried out to evaluate the hypoglycemic and hypolipidemic activity of ethyl aceteta extract flower extract of Alangium salviifolium (Linn. F). in STZ induced diabetic rats. Diabetes was induced into albino Wistar rats by intraperitonial administration of STZ. Blood samples were collected from overnight fasted normal and diabetic rats on 1th, 5th, 10th and 15th days of tre...