RESEARCH DESIGN AND METHODSdA 2-year, prospective, randomized, open-label, placebo-controlled study was carried out in pregnant outpatients with a parent with type 2 diabetes who were treated from the end of the first trimester with 2 gmyo-inositol plus 200 mg folic acid twice a day (n = 110) and in the placebo group (n = 110), who were only treated with 200 mg folic acid twice a day. The main ...

Pregnant women with gestational diabetes mellitus (GDM) are at risk for certain neonatal complications. The International Association of the Diabetes and Pregnancy Study Groups (IADPSG) blood glucose level (BGL) diagnostic thresholds correspond to an odds ratio of at least 1.75 for selected complications (1). In the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study (2), 16.1% of subjects...

The recently completed National Institutes of Health (NIH) (1) consensus development conference on the diagnosis of gestational diabetes mellitus (GDM) found insufficient evidence to change from current practice to that recommended by the American Diabetes Association (2). The NIH final statement identified some key research gaps, the first mentioned of which was to “evaluate the diagnostic thr...

The American Diabetes Association published new recommendations for the detection and diagnosis of gestational diabetes mellitus in 2011 (1). These criteria were based on the consensus opinion of the International Association of the Diabetes and Pregnancy Study Groups (IADPSG) (2). The Australasian Diabetes in Pregnancy Society (ADIPS) has posted new guidelines (www.adips. org) to replace those...

Various challenge tests have been used around the world for the diagnosis of gestational diabetes mellitus (GDM), and substantial variation among these methods has been noted, not only in the amount of glucose for the challenge and the testing intervals but also in the concentration thresholds used for interpretation. The interpretive criteria for these testing approaches have variably been bas...