genus peucedanum belongs to the subfamily of apioideae (umbelliferae family) and is reported to have many medicinal properties. several spiecis of peucedum reported to have antispasmodic activity. p eucedanum pastinacifolium species grows in iran. however, so far there is no report on its antispasmodic activity. the objective of this research was to investigate antispasmodic activities of p. pa...

seeds of moringa peregrina (forssk.) fiori. (moringaceae) is widely used in south east of iran for gastrointestinal disorders. however, so far there is no pharmacological evidence for antispasmodic activity of this plant extract. therefore, the aim of this research was to investigate antispasmodic activity of m. peregrina on rat isolated ileum contraction. hydroalcoholic extract was obtained by...

a series of 3-hydroxypyridin-4-one derivatives (hpos) were synthesized and their partition coefficient values (k part ) were determined. the cytotoxic effects of these iron chelators against hela cancer cells were also evaluated. the ic 50 of hpos was determined using mtt assay. among these ligands, compound 4e (k part =5.02) with an ic 50 of 30 µm and 4f (k part =0.1) with an ic 50 of 700 µm s...

Trifolium repens L., commonly referred as white clover, is one of the important stoloniferous perennial range legume growing in temperate regions. The introduction forage legumes agro-ecosystem provides nitrogen enrichment soil and mobilizes other nutrients. Further, it has a tremendous potential to help rehabilitate grasslands decrease severe fodder shortage Himalayan region. In recent decades...

U937 monocytic cells are shown here to express a range of PDE4, cAMP-specific phosphodiesterase (PDE) isoenzymes: the long isoenzymes, PDE4A4, PDE4D5 and PDE4D3, plus the short isoenzyme, PDE4B2. These isoenzymes provide around 76% of the total cAMP PDE activity of U937 cells. The specific activities of the total PDE4A, PDE4B and PDE4D activities were 0.63+/-0.09, 8.8+/-0.2 and 34.4+/-2.9 pmol/...

Maraviroc (MVC) gels are effective at protecting rhesus macaques from vaginal SHIV transmission, but breakthrough infections can occur. To determine the effects of a vaginal MVC gel on infecting SHIV populations in a macaque model, we analyzed plasma samples from three rhesus macaques that received a MVC vaginal gel (day 0) but became infected after high-dose SHIV-162P3 vaginal challenge. Two i...

Objetivos: Determinar la frecuencia y los factores asociados a depresión, ansiedad suicidalidad en una población de Lima Metropolitana durante pandemia por el virus SARS-CoV2. Material métodos: Estudio observacional, transversal analítico; tipo muestreo fue no probabilístico “bola nieve”, se utilizaron dos encuestas virtuales, Escala Psicopatología Depresiva-6 Ansiedad Lima-20. Se calcularon ra...

background and purpose: invasive candidiasis (ic) is a significant cause of morbidity and mortality in patients with hematologic disorders and bone marrow transplant recipients. rapid, specific and sensitive test for the timely accuracy in immunocompromised patients to reduce mortality rates and prevent ic progress is necessary. we established a real-time pcr assay on blood for the diagnosis an...