Puberty is the period of transition from childhood to adulthood characterized by attainment adult height and body composition, accrual bone strength acquisition secondary sexual characteristics, psychosocial maturation reproductive capacity. In girls, menarche a late marker puberty. Primary amenorrhea defined as absence in ≥ 15-year-old females with developed characteristics normal growth or ≥1...

OBJECTIVE To investigate puberty in a group of thalassemic patients with delayed or arrested pubertal development and to compare the effects of hormonal and L-carnitine therapy on puberty in those patients. PATIENTS Thirty-two -thalassemic patients with arrested or failure of puberty were enrolled for 1 year in this study. METHOD Clinical pubertal assessment and laboratory investigations we...

OBJECTIVE To investigate the causes of amenorrhea in Korean women. METHODS Medical records from 1,212 women with amenorrhea who visited the Department of Obstetrics and Gynecology, Asan Medical Center, between January 1989 and December 2011 were retrospectively reviewed. Amenorrhea was categorized as either primary or secondary. RESULTS Primary amenorrhea was identified in 132 of the patien...

OBJECTIVES Autoimmune targeting of hypothalamic-neurohypophyseal structures in children and young adults with posterior pituitary and anterior pituitary dysfunction, as well as pituitary stalk involvement, are not yet completely understood. DESIGN We aimed to (1) evaluate the presence of circulating vasopressin-cell autoantibodies (AVPc-Abs) in young patients with central diabetes insipidus (...

We present the cases of two children with presumed idiopathic central diabetes insipidus whose follow-up MR studies eventually revealed hypothalamic tumors. Thin-section sagittal T1-weighted MR with gadolinium administration is important in the evaluation of these children, and serial examinations are probably necessary.

This article has demonstrated that stress and HPA axis activation affect the reproductive axis. Despite similarities in the HPA axis picture between women with major depression and those with hypothalamic amenorrhea and exercise or nutritional amenorrhea, no abnormalities in LH secretion have been documented in major depression. Lower estradiol in the follicular phase in depressed women and low...