In some patients with antibodies against LPS antigen of Chlamydia, specific immunoglobulins G are not present. The findings of isolated anti-LPS IgA/IgM antibodies are to be considered as possibly non-specifically or "false" positive. The aim of this study was to investigate if there is any difference in the level of total immunoglobulins of isotypes IgG and IgG2 in probands with isolated posit...

The serotype b-specific carbohydrate antigen (SbAg) of Actinobacillus actinomycetemcomitans Y4 is reported to be the O antigen of lipopolysaccharide, and the highest titers of serum antibody reactive with A. actinomycetemcomitans in early-onset periodontitis (EOP) patients bind SbAg. These high titers of serum antibody reactive with SbAg are associated with a lesser extent and severity of perio...

Anti-Ig induced redistribution of different Ig subclasses was studied as a function of temperature and correlated with membrane phase transitions as revealed by electron spin resonance spectroscopy. Fluorescein isothiocyanate-coupled anti-IgG2 and anti-IgM antibodies induced patching and capping that proceeded with increasing rates from 2 degrees to 40 degrees (measured at 2 degrees intervals)....

Pigs infected with T. spiralis and T. britovi were followed by double (IgG) and triple antibody ELISA (IgG1, IgG2 and IgM) during a 12-week-period. Specific IgG and IgG1 responses were similar and showed a significant relation with the infecting doses and intensity of infection. Response to T. britovi was slightly lower than in groups infected with the same dose of T. spiralis. IgG2 response wa...

The expression of IgG, IgG1 and IgG2 specific antibodies for Leishmania infantum was studied in five groups of dogs in Catalonia (Spain): I, 99 asymptomatic dogs (infected and uninfected) from a highly endemic area for leishmaniosis; II, 139 untreated dogs with clinically patent leishmaniosis; III, 11 naturally infected asymptomatic dogs monitored for up to 5 years since they were found seropos...

The FcγRIIA/CD32A is mainly expressed on platelets, myeloid and several endothelial cells. Its affinity considered insufficient for allowing significant binding of monomeric IgG, while its H131R polymorphism (histidine > arginine at position 131) influences multimeric IgG2. Platelet FcγRIIA has been reported to contribute IgG-containing immune-complexe clearance. Given our finding that plate...

T2D4, a T-cell hybrid, spontaneously secretes suppressive immunoglobulin factor(s); when incubated with purified monoclonal mouse immunoglobulins, this hybrid produces high levels of immunoglobulin-binding factors specific for the subclass of the inducing immunoglobulin. Thus, we were able to induce the production of IgG1- or IgG2-specific inhibitory factors by the same T2D4 T-cell hybrid. Thes...

Objectives—Polymorphism of the phagocyte IgG receptor FcãRIIa may modulate immune complex mediated inflammation, particularly when immune complexes contain IgG2. Previous studies suggest that this polymorphism may be an important risk factor for lupus nephritis. FcãRIIa is biallelic, the alleles R and H each having a gene frequency of about 50%. Nephritis has been associated with an increased f...

purpose: evaluation of humoral and cellular immune responses of naturally infected dogs against type i (rcpb) (recombinant cycsteine proteinase b), and ii (rcpa) (recombinant cycsteine proteinase a) recombinant cysteine proteinases and c-terminal extension (cte) of leishmania infantum (l. infantum). materials and methods: in this study, fourteen infected dogs (7 with symptoms, 7 asymptomatics)...